Impact of Aortic Valve Disease and Thoracic Aortic Aneurysm on Kinocardiographic Signals

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Kinocardiography (KCG) is a portable measurement technique developed to estimate cardiac mechanical performance by studying the vibrations produced by myocardial contraction during each heartbeat and transmitted to the body surface. The goal of this observational study is to learn about kinocardiography in patients with aortic valve disease (AVD) or thoracic aortic aneurysm (TAA). The investigators believe that this technology will enable to diagnose aortic valve disease and aortic aneurysm. In patients with AVD of different severities or TAA, the investigators will collect informations from echocardiography and/or cardiac magnetic resonance imaging, KCG recordings, phonocardiography (PCG) recordings, and video recordings. Researchers will also compare subjects without any AVD nor TAA to better understand these effects on KCG, PCG and video signal.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Interventional treatment group

‣ Adults (\>18 y)

⁃ Interventional treatment indication for severe AVD and/or severe TAA, as decided by the Heart Team

• Aortic valve disease of different severities group

‣ Adults (\>18y)

⁃ Aortic stenosis and/or aortic regurgitation and/or bicuspidy of different severities confirmed by echocardiography and/or cardiac MRI

• Control group : - Adults (\>18 y) appariated with the participants of other groups according to their age, sex, body surface area and LVEF

Locations
Other Locations
Belgium
Erasme hospital
RECRUITING
Brussels
Contact Information
Primary
Elza Abdessater, MD
elza.abdessater@ulb.be
2 555 32 75
Backup
Philippe van de Borne, MD, PhD
philippe.vandeborne@hubruxelles.be
2 555 39 60
Time Frame
Start Date: 2024-03-07
Estimated Completion Date: 2025-09-30
Participants
Target number of participants: 180
Treatments
Interventional treatment
Patients with severe aortic valve disease or thoracic aortic aneurysm in whom interventional treatment has been previously decided by the Heart Team (i.e. the multidisciplinary team of cardiologists and cardiac surgeons treating the patient, independently of the research team) Patients with different severities of AVD or TAA, and healthy subjects. The KCG measurements and video recordings are consecutive to an echocardiography or cardiac MRI, and will be carried out in Erasme hospital.
Aortic valve disease of different severities
Patients with aortic stenosis and/or aortic regurgitation and/or bicuspidy of different severities. The KCG measurements consecutive to the echocardiography and/or cardiac MRI will be carried out during their clinical management in Erasme hospital.
Control
Subjects matched to the two other groups according to their age, gender, body surface area and left ventricular ejection fraction (LVEF), without AVD or TAA. The KCG measurements will be made immediately after the echocardiography and/or MRI in Erasme hospital.
Related Therapeutic Areas
Sponsors
Collaborators: Erasme University Hospital
Leads: Université Libre de Bruxelles

This content was sourced from clinicaltrials.gov