Initial Safety and Performance of the CellFX® nsPFA™ Cardiac Surgery System for the Treatment of Atrial Fibrillation

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This feasibility study will be conducted to demonstrate the initial safety and effectiveness of the CellFX® nsPFA™ Cardiac Clamp in performing a box lesion around the 4 pulmonary veins as an isolated procedure or as a part of a more extensive surgical ablation set in conjunction with concomitant cardiac surgical procedure.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:

• Subject must be between 18 and 85 years of age

• Subject is willing and capable of providing Informed Consent to undergo study procedures which includes surgical AF ablation and completing follow-up visits as specified in the clinical study protocol

• Subject has history of documented atrial fibrillation within one year prior to enrollment. Documentation may include ECG, transtelephonic monitor (TTM), holter monitor or telemetry strip

• Subject is scheduled to undergo non-emergent cardiac surgical procedure(s) to be performed on cardiopulmonary bypass including open-heart surgery for one or more of the following: Mitral valve repair or replacement, Aortic valve repair or replacement, Ascending aortic aneurysms, or Coronary artery bypass procedures

• Left ventricular ejection fraction ≥ 30% (determined by echocardiography or cardiac catheterization performed within 60 days of enrollment as documented in patient medical history)

• Subject has a life expectancy of at least 5 years

Locations
Other Locations
Netherlands
Academic Medical Center
RECRUITING
Amsterdam
Maastricht University Medical Center+ (MUMC+)
RECRUITING
Maastricht
St. Antonius Hospital
RECRUITING
Nieuwegein
Contact Information
Primary
William A. Knape
bknape@pulsebiosciences.com
+1 (919) 757-2033
Backup
Aleksandra Kurek
aleksandra.kurek@pulsebiosciences.com
+44 745 6655949
Time Frame
Start Date: 2024-07-31
Estimated Completion Date: 2025-10-31
Participants
Target number of participants: 30
Treatments
Experimental: CellFX nsPFA Treatment Arm
Adult subjects who are clinically indicated for a concomitant cardiac surgical procedure will undergo left pulmonary vein, roof and floor ablations to form a left atrial posterior box using the CellFX® nsPFA™ Cardiac Surgery System.
Sponsors
Leads: Pulse Biosciences, Inc.

This content was sourced from clinicaltrials.gov