Patient Specific Biomechanical Modeling of Abdominal Aortic Aneurysm to Improve Aortic Endovascular Repair

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This project is aiming at the integration of a biomechanical computer program with a guidance code to simulate the endovascular repair (EVAR) procedure of abdominal aortic aneurysm (AAA). The computational time associated with finite element simulation generally renders its usage impractical for real-time application. Based on data collected during clinical interventions and a priori knowledge of AAA and endovascular device mechanical modeling, the investigators are proposing a deformable registration between preoperative CT-scans and per-operative fluoroscopy that will take into account prior simulations of participant specific EVAR procedures. To avoid the computational cost of a full finite element simulation, the investigators propose a simplified and real-time compliant repetitive mechanical behaviour based on participant specific parameters. The results of this research will provide the Canadian industry with the first realistic deformable vascular geometry tool for live endovascular intervention guidance. The proposed biomechanical modeling can be translated to other vascular intervention procedure by adjusting the biomechanical parameters.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Patients with a clinical indication for EVAR/FEVAR of AAA and meeting anatomic inclusion criteria on preoperative enhanced CT-scan compatible with an endovascular repair.

• Willing and capable of providing informed consent

Locations
Other Locations
Canada
Centre Hospitalier de l'université de Montréal
RECRUITING
Montreal
Contact Information
Primary
Jennifer Satterthwaite, MSc
jennifer.satterthwaite.chum@ssss.gouv.qc.ca
514-890-8000
Backup
Andrée Cliche, MSc
andree.cliche.chum@ssss.gouv.qc.ca
514-890-8000
Time Frame
Start Date: 2020-10-01
Estimated Completion Date: 2026-05-29
Participants
Target number of participants: 20
Treatments
Experimental: Rigid and Elastic registration softwares
Sponsors
Leads: Centre hospitalier de l'Université de Montréal (CHUM)
Collaborators: Siemens Corporation, Corporate Technology, MedTeq, Natural Sciences and Engineering Research Council, Canada

This content was sourced from clinicaltrials.gov