Throat Cancer

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Throat Cancer?

Throat cancer is cancer of the vocal cords, larynx (voice box), or other areas of the throat.

What are the alternative names for Throat Cancer?

Vocal cord cancer; Throat cancer; Laryngeal cancer; Cancer of the glottis; Cancer of oropharynx or hypopharynx; Cancer of the tonsils; Cancer of the base of the tongue

What are the causes for Throat Cancer?

People who smoke or use tobacco are at risk of developing throat cancer. Drinking too much alcohol over a long time also increases risk. Smoking and drinking alcohol combined lead to an increased risk for throat cancer.

Most throat cancers develop in adults older than 50. Men are more likely than women to develop throat cancer.

Human papillomavirus (HPV) infection (the same virus that causes genital warts) account for a larger number of oral cancers than in the past. One type of HPV, type 16 or HPV-16, is much more commonly associated with almost all oral cancers.

What are the symptoms for Throat Cancer?

Symptoms of throat cancer include any of the following:

  • Abnormal (high-pitched) breathing sounds
  • Cough
  • Coughing up blood
  • Difficulty swallowing
  • Hoarseness that does not get better in 3 to 4 weeks
  • Neck or ear pain
  • Sore throat that does not get better in 2 to 3 weeks, even with antibiotics
  • Swelling or lumps in the neck
  • Weight loss not due to dieting

What are the current treatments for Throat Cancer?

The goal of treatment is to completely remove the cancer and prevent it from spreading to other parts of the body.

When the tumor is small, either surgery or radiation therapy alone can be used to remove the tumor.

When the tumor is larger or has spread to lymph nodes in the neck, a combination of radiation and chemotherapy is often used to save the voice box (vocal cords). If this is not possible, the voice box is removed. This surgery is called a laryngectomy.

Depending on what type of treatment you require, supportive treatments that may be needed include:

  • Speech therapy.
  • Therapy to help with chewing and swallowing.
  • Learning to eat enough protein and calories to keep your weight up. Ask your health care provider about liquid food supplements that can help.
  • Help with dry mouth.

What are the support groups for Throat Cancer?

You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.

What is the outlook (prognosis) for Throat Cancer?

Throat cancers may be cured when detected early. If the cancer has not spread (metastasized) to surrounding tissues or lymph nodes in the neck, about one half of patients can be cured. If the cancer has spread to the lymph nodes and parts of the body outside the head and neck, the cancer is not curable. Treatment is aimed at prolonging and improving quality of life.

It is possible but not fully proven that cancers which test positive for HPV may have better outlooks. Also, people who smoked for less than 10 years may do better. 

After treatment, therapy is needed to help with speech and swallowing. If the person is not able to swallow, a feeding tube will be needed.

The recurrence risk in throat cancer is highest during the first 2 to 3 years of diagnosis.

Regular follow-up after the diagnosis and treatment is very important to increase the chances of survival.

What are the possible complications for Throat Cancer?

Complications of this type of cancer may include:

  • Airway obstruction
  • Difficulty swallowing
  • Disfigurement of the neck or face
  • Hardening of the skin of the neck
  • Loss of voice and speaking ability
  • Spread of the cancer to other body areas (metastasis)

When should I contact a medical professional for Throat Cancer?

Call your provider if:

  • You have symptoms of throat cancer, especially hoarseness or a change in voice with no obvious cause that lasts longer than 3 weeks
  • You find a lump in your neck that does not go away in 3 weeks

How do I prevent Throat Cancer?

Do not smoke or use other tobacco. Limit or avoid alcohol use.

HPV vaccines recommended for children and young adults target HPV subtypes most likely to cause some head and neck cancers. They have been shown to prevent most oral HPV infections. It is not clear yet whether they also are able to prevent throat or larynx cancers.



Armstrong WB, Vokes DE, Verma SP. Malignant tumors of the larynx. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 6th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 106.

Fakhry C, Gourin CG. Human papillomavirus and the epidemiology of head and neck cancer. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 6th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 75.

Garden AS, Beadle BM, Morrison WH. Larynx and hypopharynx cancer. In: Gunderson LL, Tepper JE, eds. Clinical Radiation Oncology. 4th ed. Philadelphia, PA: Elsevier; 2016:chap 35.

Lorenz RR, Couch ME, Burkey BB. Head and neck. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 20th ed. Philadelphia, PA: Elsevier; 2017:chap 33.

National Cancer Institute website. Nasopharyngeal cancer treatment (adult) (PDQ) - health professional version. Updated January 12, 2018. Accessed January 31, 2018.

Latest Research

Latest Advance
  • Condition: Vocal Cord Reconstruction
  • Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • Treatment Used: Vertical Anterior Laryngectomy with Pedicled Sternohyoid Flap
  • Number of Patients: 43
  • Published —
This study tested the safety and efficacy of using a vertical anterior laryngectomy with a pedicled sternohyoid flap to treat patients requiring vocal cord reconstruction.
Latest Advance
  • Condition: Larynx Carcinoma
  • Journal: BMC cancer
  • Treatment Used: Total Laryngectomy
  • Number of Patients: 69
  • Published —
This study investigated whether thyroid excision is required for optimal clinical outcomes in patients undergoing total laryngectomy for their larynx carcinoma.

Clinical Trials

Clinical Trial
  • Status: Not yet recruiting
  • Study Type: Other
  • Participants: 264
  • Start Date: December 2020
Clinical Trial
  • Status: Not yet recruiting
  • Study Type: Drug
  • Participants: 104
  • Start Date: December 1, 2020
A 12-Week Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Assess the Efficacy of Fosamprenavir/Lexiva for Laryngopharyngeal Reflux (LPR)