• Aged ≥18 years old, male or female;

• Conform to the diagnostic criteria of chemotherapy-induced thrombocytopenia (CIT); Ineffective after repeated treatment with rhTPO or IL-11；

• Stop radiotherapy or chemotherapy for more than 1 month;

• Platelet counts \<30 ×10\^9/L, and bleeding tendency;

• Estimated survival period ≥ 6 months；

• People who are willing to sign the informed consent voluntarily and follow the research program.

• Liver and kidney function\<1.5×upper limit of normal, qualified for physical examination；

• Subject is practicing an acceptable method of contraception. Women of childbearing potential must have a negative serum pregnancy test in the whole study;