Cold Versus Room Temperature Storage of Platelets for Bleeding in Hematologic Malignancy - a Pilot Trial
Status: Recruiting
Location: See location...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
This is a pilot trial to discover the feasibility of recruiting 50 pts over the course of 12 months. The trial is testing the efficacy of using cold-stored vs. room temperature stored (current standard of care) platelets to treat bleeding in persons with hematological disorders and thrombocytopenia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adult patients (age ≥ 18) admitted to Malignant Hematology ward with hematologic malignancy or marrow aplasia, this may include patients undergoing chemotherapy, immunotherapy, or hematopoietic stem cell transplant or patients admitted for symptom management.
• Moderate thrombocytopenia, platelet concentration 10-100 x109/L
• Platelet transfusion ordered to treat bleeding
Locations
Other Locations
Canada
The Ottawa Hospital - General Campus
RECRUITING
Ottawa
Contact Information
Primary
Johnathan M Mack, MD
johnathan.mack.med@ssss.gouv.qc.ca
514-934-1934
Backup
Alan Tinmouth, MD
atinmouth@toh.on.ca
613-737-8899
Time Frame
Start Date: 2025-05-16
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 50
Treatments
Experimental: Cold-stored platelet concentrate
Cold-stored, pathogen-reduced platelet transfusion
Other: Room temperature-stored platelet concentrate
Room temperature-stored, pathogen reduced platelet transfusion
Related Therapeutic Areas
Sponsors
Leads: Ottawa Hospital Research Institute