Impact of Thrombocytopenia and Platelet Transfusions on Neonatal Bleeding and Inflammation
Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY
Aims: 1. To determine whether the Immature Platelet Fraction percentage (IPF%) and the Immature Platelet Count (IPC) are better predictors of bleeding than the platelet count alone in neonates of different gestational and post-conceptional ages and with different etiologies of thrombocytopenia; and 2. To characterize the effects of neonatal thrombocytopenia and platelet transfusions (PLT Tx) on bleeding and on markers of systemic inflammation, thrombosis, and neutrophil extracellular traps (NET) formation in neonates with different underlying conditions.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 6 months
Healthy Volunteers: f
View:
• Have a post-menstrual age between 23 and 44 weeks;
• Have a PLT count \<100 x 109/L; and
• Have a parent/guardian willing to provide written informed consent.
Locations
United States
Massachusetts
Beth Israel Deaconess Medical Center
RECRUITING
Boston
Boston Children's Hospital
RECRUITING
Boston
Contact Information
Primary
Martha Sola-Visner, MD
martha.sola-visner@childrens.harvard.edu
617-919-4845
Backup
Vanessa J Young, RN, BA
vanessa.young@childrens.harvard.edu
617-355-8330
Time Frame
Start Date: 2019-08-19
Estimated Completion Date: 2026-09-01
Participants
Target number of participants: 160
Related Therapeutic Areas
Sponsors
Collaborators: Beth Israel Deaconess Medical Center, National Heart, Lung, and Blood Institute (NHLBI)
Leads: Boston Children's Hospital