Learn About Thrombophlebitis

What is the definition of Thrombophlebitis?

Thrombophlebitis is swelling (inflammation) of a vein. A blood clot (thrombus) in the vein can cause this swelling.

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What are the alternative names for Thrombophlebitis?

Phlebitis; Deep vein thrombosis - thrombophlebitis; Thrombophilia - thrombophlebitis

What are the causes of Thrombophlebitis?

Thrombophlebitis may affect deeper, larger veins or veins near the skin surface. Most of the time, it occurs in the pelvis and legs.

Blood clots may form when something slows or changes the flow of blood in the veins. Risk factors include:

  • A pacemaker catheter that has been passed through the vein in the groin
  • Bed rest or sitting in one position for too long, such as plane travel
  • Family history of blood clots, which may imply the presence of inherited disorders that lead to increased risk of clots. Common ones include deficiency or lack of antithrombin, protein C, and protein S, factor V Leiden (FVL) and prothrombin
  • Fractures in the pelvis or legs
  • Giving birth within the last 6 months
  • Pregnancy
  • Obesity
  • Recent surgery (most commonly hip, knee, or female pelvic surgery)
  • Too many blood cells being made by the bone marrow, causing the blood to be thicker than normal (polycythemia vera)
  • Having an indwelling (long-term) catheter in a blood vessel

Blood is more likely to clot in someone who has certain problems or disorders, such as:

  • Cancer
  • Certain autoimmune disorders, such as lupus
  • Cigarette smoking
  • Conditions that make it more likely to develop blood clots
  • Taking estrogens or birth control pills (this risk is even higher with smoking)
What are the symptoms of Thrombophlebitis?

The following symptoms are often associated with thrombophlebitis:

  • Swelling in the part of the body affected
  • Pain in the part of the body affected
  • Skin redness (not always present)
  • Warmth and tenderness over the vein
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What are the current treatments for Thrombophlebitis?

Support stockings and wraps can help to reduce discomfort. Your provider may prescribe medicines such as:

  • Painkillers
  • Blood thinners to prevent new clots from forming, most often only prescribed when deep veins are involved
  • Medicines such as ibuprofen to reduce pain and swelling
  • Medicines injected into the vein to dissolve an existing clot

You may be told to do the following:

  • Keep pressure off the area to reduce pain and decrease the risk for further damage.
  • Raise the affected area to reduce swelling.

Rare treatment options are:

  • Surgical removal of a vein near the surface
  • Vein stripping
  • Bypass of the vein
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What is the outlook (prognosis) for Thrombophlebitis?

Prompt treatment can treat thrombophlebitis and its other forms.

What are the possible complications of Thrombophlebitis?

Complications of thrombosis include:

  • Blood clot in the lungs (pulmonary embolism)
  • Chronic pain
  • Swelling in the leg
When should I contact a medical professional for Thrombophlebitis?

Contact your provider if you have symptoms of thrombophlebitis.

Contact your provider right away if:

  • Your symptoms do not improve with treatment.
  • Your symptoms get worse.
  • New symptoms occur (such as an entire limb becoming pale, cold, or swollen).
How do I prevent Thrombophlebitis?

Routine changing of intravenous (IV) lines helps to prevent thrombophlebitis related to IVs.

If you are taking a long car or plane trip:

  • Walk or stretch your legs once in a while
  • Drink plenty of liquids
  • Wear support hose

If you are hospitalized, your provider may prescribe medicine to prevent thrombophlebitis.

Deep venous thrombosis - iliofemoral
Venous blood clot
What are the latest Thrombophlebitis Clinical Trials?
Choice of the Optimal Method for Treatment of Acute Thrombophlebitis of the Varicose Great Saphenous Vein: Comparison of Endovenous Laser Ablation and Conservative Approach

Summary: Рrospective single-centre randomized open-label study for comparison three modes of treatment for thrombosis of varicose great saphena vein - standard medical with fondaparinux sodium for 45 days, endovenous laser ablation close to the saphenofemoral junction with a 7-day course of anticoagulation and endovenous laser ablation close to the saphenofemoral junction without the use of anticoagulants.

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Imaging Research on Anatomical Variation of Cerebral Venous Sinus in Healthy Individuals

Summary: The anatomical characteristics of veins and venous sinus result in great differences between cerebral venous system diseases and cerebral artery diseases in etiology, pathophysiology and clinical features.Therefore, understanding the anatomy and variation of normal venous sinuses is essential to identify the intracranial venous lesions.

What are the Latest Advances for Thrombophlebitis?
The acceptability of the AMBITION-cm treatment regimen for HIV-associated cryptococcal meningitis: Findings from a qualitative methods study of participants and researchers in Botswana and Uganda.
Myometritis with pelvic septic vein thrombophlebitis secondary to Fusobacterium necrophorum sepsis.
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Endoscopic transversus abdominis release in the treatment of midline incisional hernias: a prospective single-center observational study on 100 patients.
Who are the sources who wrote this article ?

Published Date: January 29, 2022
Published By: Linda J. Vorvick, MD, Clinical Associate Professor, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Wasan S. Superficial thrombophlebitis and its management. In: Sidawy AN, Perler BA, eds. Rutherford's Vascular Surgery and Endovascular Therapy. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 151.

Weitz JI, Ginsberg JS. Venous thrombosis and embolism. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 74.