Learn About Thrombotic Thrombocytopenic Purpura

What is the definition of Thrombotic Thrombocytopenic Purpura?

Thrombotic thrombocytopenic purpura is a rare disorder that causes blood clots (thrombi) to form in small blood vessels throughout the body. These clots can cause serious medical problems if they block vessels and restrict blood flow to organs such as the brain, kidneys, and heart. Complications resulting from these clots can include neurological problems (such as personality changes, headaches, confusion, and slurred speech), fever, abnormal kidney function, abdominal pain, and heart problems.

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What are the causes of Thrombotic Thrombocytopenic Purpura?

Mutations in the ADAMTS13 gene cause the familial form of thrombotic thrombocytopenic purpura. The ADAMTS13 gene provides instructions for making an enzyme that is involved in the normal process of blood clotting. Mutations in this gene lead to a severe reduction in the activity of this enzyme. The acquired form of thrombotic thrombocytopenic purpura also results from a reduction in ADAMTS13 enzyme activity; however, people with the acquired form do not have mutations in the ADAMTS13 gene. Instead, their immune systems make specific proteins called autoantibodies that block the activity of the enzyme.

How prevalent is Thrombotic Thrombocytopenic Purpura?

The precise incidence of thrombotic thrombocytopenic purpura is unknown. Researchers estimate that, depending on geographic location, the condition affects 1.7 to 14.5 per million people each year in the United States. For unknown reasons, the disorder occurs more frequently in women than in men. The acquired form of thrombotic thrombocytopenic purpura is much more common than the familial form.

Is Thrombotic Thrombocytopenic Purpura an inherited disorder?

The familial form of thrombotic thrombocytopenic purpura is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Who are the top Thrombotic Thrombocytopenic Purpura Local Doctors?
Distinguished
Highly rated in
40
conditions
Hematology Oncology
Hematology

Orlando Health

Orlando Health UF Health Cancer Center

7472 Docs Grove Cir 
Orlando, FL 32819

Sreeram Maddipatla is a Hematologist Oncology specialist and a Hematologist in Orlando, Florida. Dr. Maddipatla has been practicing medicine for over 22 years and is rated as a Distinguished doctor by MediFind in the treatment of Thrombotic Thrombocytopenic Purpura. He is also highly rated in 40 other conditions, according to our data. His top areas of expertise are Sickle Cell Disease, Thrombotic Thrombocytopenic Purpura, Immune Thrombocytopenia, and Marginal Zone Lymphoma. He is licensed to treat patients in Florida. Dr. Maddipatla is currently accepting new patients.

Distinguished
Highly rated in
26
conditions
Hematology Oncology
Hematology
Oncology

Catholic Health

GSH Oncology Associates - West Islip The Cancer Institute

111 Beach Dr 
West Islip, NY 11795

Emmanuel Sygaco is a Hematologist Oncology specialist and a Hematologist in West Islip, New York. Dr. Sygaco has been practicing medicine for over 36 years and is rated as a Distinguished doctor by MediFind in the treatment of Thrombotic Thrombocytopenic Purpura. He is also highly rated in 26 other conditions, according to our data. His top areas of expertise are Thrombotic Thrombocytopenic Purpura, Immune Thrombocytopenia, Small Cell Lung Cancer, and Colorectal Cancer. He is licensed to treat patients in New York.

 
 
 
 
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Distinguished
Highly rated in
17
conditions
Hematology Oncology

Vidant Health

ECU Physicians - Hematology/Oncology

524 Moye Blvd 
Greenville, NC 27834

Charles Knupp is a Hematologist Oncology doctor in Greenville, North Carolina. Dr. Knupp has been practicing medicine for over 46 years and is rated as a Distinguished doctor by MediFind in the treatment of Thrombotic Thrombocytopenic Purpura. He is also highly rated in 17 other conditions, according to our data. His top areas of expertise are Hereditary Hemorrhagic Telangiectasia, Thrombotic Thrombocytopenic Purpura, Sickle Cell Disease, and Immune Thrombocytopenia. He is licensed to treat patients in North Carolina. Dr. Knupp is currently accepting new patients.

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Who are the sources who wrote this article ?

Published Date:updated Last, May

Published By: National Institutes of Health

What are the Latest Advances for Thrombotic Thrombocytopenic Purpura?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.