Thrombotic Thrombocytopenic PurpuraSymptoms, Doctors, Treatments, Advances & More
Learn About Thrombotic Thrombocytopenic Purpura
Thrombotic thrombocytopenic purpura is a rare disorder that causes blood clots (thrombi) to form in small blood vessels throughout the body. These clots can cause serious medical problems if they block vessels and restrict blood flow to organs such as the brain, kidneys, and heart. Complications resulting from these clots can include neurological problems (such as personality changes, headaches, confusion, and slurred speech), fever, abnormal kidney function, abdominal pain, and heart problems.
Mutations in the ADAMTS13 gene cause the familial form of thrombotic thrombocytopenic purpura. The ADAMTS13 gene provides instructions for making an enzyme that is involved in the normal process of blood clotting. Mutations in this gene lead to a severe reduction in the activity of this enzyme. The acquired form of thrombotic thrombocytopenic purpura also results from a reduction in ADAMTS13 enzyme activity; however, people with the acquired form do not have mutations in the ADAMTS13 gene. Instead, their immune systems make specific proteins called autoantibodies that block the activity of the enzyme.
The precise incidence of thrombotic thrombocytopenic purpura is unknown. Researchers estimate that, depending on geographic location, the condition affects 1.7 to 14.5 per million people each year in the United States. For unknown reasons, the disorder occurs more frequently in women than in men. The acquired form of thrombotic thrombocytopenic purpura is much more common than the familial form.
The familial form of thrombotic thrombocytopenic purpura is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
BHMA Cancer Care- Johnson City
Hesham Hazin is a Hematologist Oncology specialist and an Oncologist practicing medicine in Johnson City, Tennessee. Dr. Hazin is rated as an Advanced provider by MediFind in the treatment of Thrombotic Thrombocytopenic Purpura. He is also highly rated in 35 other conditions, according to our data. His clinical expertise encompasses Inflammatory Breast Cancer, Familial Colorectal Cancer, Colorectal Cancer, Lynch Syndrome, and Bone Marrow Aspiration. Dr. Hazin is board certified in American Board Of Internal Medicine.
Advocate Medical Group Oncology
Nandini Kalakota is a Hematologist and an Oncologist practicing medicine in Chicago, Illinois. Dr. Kalakota is rated as an Experienced provider by MediFind in the treatment of Thrombotic Thrombocytopenic Purpura. Her clinical expertise encompasses Lung Cancer, Pleuropulmonary Blastoma, Non-Small Cell Lung Cancer (NSCLC), and Lung Adenocarcinoma. Dr. Kalakota is board certified in American Board Of Internal Medicine, Hematology.
Advocate Good Samaritan Cancer Center
Ilia Sumoza is a Hematologist and an Oncologist practicing medicine in Downers Grove, Illinois. Dr. Sumoza is rated as an Experienced provider by MediFind in the treatment of Thrombotic Thrombocytopenic Purpura. She is also highly rated in 11 other conditions, according to our data. Her clinical expertise encompasses Breast Cancer, Colorectal Cancer, Paget Disease of the Breast, and Familial Colorectal Cancer. Dr. Sumoza is board certified in American Board Of Internal Medicine, Hematology.
Published Date: May 01, 2020
Published By: National Institutes of Health
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