Learn About Tieche-Jadassohn Nevus

What is the definition of Tieche-Jadassohn Nevus?
Tièche-Jadassohn nevus are rare blue moles that have several different types. Blue moles are more common in women and Asians, and mostly occur in late childhood or adolescence. Common blue moles are benign and do not change over the course of a lifetime. However, in rare instances, cellular blue moles can become a form of malignant melanoma. Blue moles are caused by incomplete migration of melanocytes, while the blue color is caused by the Tyndall effect, where shorter wavelengths of incident light are scattered by melanocytes (melanin-forming cells). Blue moles are usually blue because their melanocytes are deeper than those of brown moles.
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What are the symptoms of Tieche-Jadassohn Nevus?
Symptoms of the common blue mole are the appearance of a single blue or bluish, smooth surfaced, round or oval macule, papule, or plaque, usually found on hands or feet, buttocks, scalp, face, or below the nail. Rarely, blue moles can appear in the vagina, cervix, spermatic cord, lymph nodes, prostate, and mouth. Common blue moles are usually 0.5-to-1 cm in diameter. Cellular blue moles are at least 1 cm and more nodular. While usually blue, these moles can also be grey, brown, or yellow.
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What are the current treatments for Tieche-Jadassohn Nevus?
Blue moles usually require no treatment; however, those on the scalp can be surgically removed as a preventative measure. Blue moles larger than 1 cm that change appearance or suddenly appear in older adults should be examined to rule out melanoma. Blue moles are also removed for cosmetic reasons.
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What are the latest Tieche-Jadassohn Nevus Clinical Trials?
A Multicenter, Ambispective, Low-interventional Clinical Study Evaluating Molecular Genetic Markers for Non-invasive Differential Diagnosis of Benign and Malignant Pigmented Skin and Mucosal Neoplasms

Summary: This is a multicenter, ambispective, low-interventional clinical study evaluating molecular genetic markers for non-invasive differential diagnosis of benign and malignant pigmented skin and mucosal neoplasms. In retrospective cohorts genetics markers will be identified. In prospective cohort non-invasive adhesive system will be tested to identify malignant or benign lesions with prespecified sens...

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Familial Investigations of Childhood Cancer Predisposition

Summary: NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic counselor or other genetics professional. If you have already had clinical genetic testing and meet eligibility...

What are the Latest Advances for Tieche-Jadassohn Nevus?
Sirolimus for management of GI bleeding in blue rubber bleb nevus syndrome: A case series.
Unilateral or bilateral adrenalectomy in PPNAD: six cases from a single family followed up over 40 years.
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Treatment of sirolimus in the pathological femoral fracture related to blue rubber bleb nevus syndrome: A case report.