Implementation and Evaluation of Vector Control Methods in Kinshasa: The Case of Aedes, Vectors of Arboviruses.

Status: Recruiting
Location: See location...
Intervention Type: Other, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Arboviral diseases are viral diseases transmitted by mosquitoes of the Aedes genus and are constantly spreading throughout the world, constituting a significant threat to public health. In Africa, there is very little data on the epidemiological situation of Aedes-borne diseases and programs for monitoring these diseases are very limited. In the Democratic Republic of the Congo (DRC), several epidemics of yellow fever, dengue fever, chikungunya and Zika cases have been reported. In particular, in Kinshasa, the dengue and chikungunya viruses have previously been detected in patients with undifferentiated fevers and several studies have shown entomological transmission indices above the criteria and standards of the World Health Organization (WHO). The aim of our study is to implement and evaluate different strategies to control Aedes mosquitoes at different stages of their life cycle in the city of Kinshasa. In particular, a before-and-after interventional study will be piloted and tested in the health zone of Kinshasa, with the aim of providing preliminary evidence of the impact of vector control tools. Interventions will be implemented in 400 households for each arm for 12 months. Before, after and during the interventions, entomological surveys will be conducted in 160 households in each arm to define the density of the vectors. Mosquitoes will be tested for the possible presence of arbovirus RNA (dengue, chikungunya, Zika, yellow fever). During the pre-intervention period, a serological survey for the same diseases transmitted by the Aedes mosquito will be conducted on a sample of 450 people included in two health centers of reference for the health zone of Mont Ngafula 1. A questionnaire will also be administered before and after the intervention implementation to assess the community's knowledge, attitudes and practices towards Aedes mosquito vector control and Aedes-borne diseases. The integration of the data collected within the scope of this study will provide an assessment of the feasibility and impact of the tested methods on entomological indicators, as well as determining the exposure and knowledge of Aedes-borne diseases in the Mont Ngafula 1 area.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Belong to a household in one of the 4 health areas selected as study arms

• From 18 years of age to consent for household enrollment and participation in the serosurvey

• Consenting

• From 18 years of age

• Resident of the health zone of Mont Ngafula 1

• Consenting

Locations
Other Locations
Democratic Republic of the Congo
Institut National de Recherche Biomédicale, INRB
RECRUITING
Kinshasa
Contact Information
Primary
Luciana Lepore
llepore@itg.be
+32(0)32476666
Backup
Wim Van Bortel
wvanbortel@itg.be
+32(0)32476666
Time Frame
Start Date: 2025-03-26
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 2050
Treatments
Experimental: ARM 1_Community-based environmental management
This intervention will be carried out by the community, who will have received training and information on the environmental management measures suitable for controlling the Aedes mosquito. It will involve a cluster of 400 households randomly assigned to this intervention.
Experimental: ARM 2_Community-based environmental management AND vector control against immature stages of Aedes
This intervention combines community-based environmental management (specified in the first study arm) with vector control against immature stages of Aedes. It will involve a cluster of 400 households randomly assigned to this intervention.
Experimental: ARM 3_Community-based environmental management AND vector control against mature stages of Aedes
This intervention combines community-based environmental management (specified in the first arm of the study) with vector control against the mature stages of Aedes. It will involve a cluster of 400 households randomly assigned to this intervention.
No_intervention: ARM 4_Control arm
No control interventions will be implemented. It will involve a cluster of 400 households randomly assigned to this arm.
Sponsors
Collaborators: Institut National de Recherche Biomédicale. Kinshasa, République Démocratique du Congo
Leads: Institute of Tropical Medicine, Belgium

This content was sourced from clinicaltrials.gov