Condition 101 About Toxic Megacolon

What is the definition of Toxic Megacolon?

Toxic megacolon occurs when swelling and inflammation spread into the deeper layers of your colon. As a result, the colon stops working and widens. In severe cases, the colon may rupture.

What are the alternative names for Toxic Megacolon?

Toxic dilation of the colon; Megarectum; Inflammatory bowel disease - toxic megacolon; Crohn disease - toxic megacolon; Ulcerative colitis - toxic megacolon

What are the causes for Toxic Megacolon?

The term "toxic" means that this problem is very dangerous. Toxic megacolon may occur in people with an inflamed colon due to:

  • Ulcerative colitis, or Crohn disease that is not well controlled
  • Infections of the colon such as Clostridioides difficile
  • Ischemic bowel disease

Other forms of megacolon include pseudo-obstruction, acute colonic ileus, or congenital colonic dilation. These conditions do not involve an infected or inflamed colon.

What are the symptoms for Toxic Megacolon?

The rapid widening of the colon may cause the following symptoms to occur over a short period of time:

  • Painful, distended abdomen
  • Fever (sepsis)
  • Diarrhea (usually bloody)

What are the current treatments for Toxic Megacolon?

Treatment of the disorder that led to toxic megacolon includes:

  • Steroids and other medicines that suppress the immune system
  • Antibiotics

If you have septic shock, you will be admitted to the intensive care unit of the hospital. Treatment may include:

  • Breathing machine (mechanical ventilation)
  • Dialysis for kidney failure
  • Drugs to treat low blood pressure, infection, or poor blood clotting
  • Fluids given directly into a vein
  • Oxygen

If rapid widening is not treated, an opening or rupture can form in the colon. If the condition doesn't improve with medical treatment, surgery will be needed to remove part or all of the colon.

You may receive antibiotics to prevent sepsis (a severe infection).

What is the outlook (prognosis) for Toxic Megacolon?

If the condition does not improve, it can be fatal. Colon surgery is usually needed in such cases.

What are the possible complications for Toxic Megacolon?

Complications may include:

  • Perforation of the colon
  • Sepsis
  • Shock
  • Death

When should I contact a medical professional for Toxic Megacolon?

Go to the emergency room or call the local emergency number (such as 911) if you develop severe abdominal pain, especially if you also have:

  • Bloody diarrhea
  • Fever
  • Frequent diarrhea
  • Rapid heart rate
  • Tenderness when the abdomen is pressed
  • Abdominal distention

How do I prevent Toxic Megacolon?

Treating diseases that cause toxic megacolon, such as ulcerative colitis or Crohn disease, can prevent this condition.



Lichtenstein GR. Inflammatory bowel disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 132.

Nishtala MV, Benlice C, Steele SR. Management of toxic megacolon. In: Cameron AM, Cameron JL, eds. Current Surgical Therapy. 13th ed. Philadelphia, PA: Elsevier; 180-185.

Peterson MA, Wu AW. Disorders of the large intestine. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 85.

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Latest Advances On Toxic Megacolon

  • Condition: Campylobacter Colitis with Toxic Megacolon and Multiple Organ Failure
  • Journal: BMJ case reports
  • Treatment Used: Antibiotics, Total Colectomy with Ileostomy
  • Number of Patients: 1
  • Published —
This case report describes a 58-year-old woman diagnosed with Campylobacter colitis with toxic megacolon and multiple organ failure treated with antibiotics, total colectomy, and ileostomy.

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