European Blood Pressure Intensive Control After Stroke - Pilot Trial
Stroke is the third most common cause of death worldwide and the leading cause of disability. High blood pressure is an important risk factor for stroke. Lowering a person's blood pressure reduces the risk of future stroke or heart attack, and current guidelines recommend treatment to a target of \<130mmHg for secondary prevention. Home blood pressure measurement and telemonitoring are acceptable to patients, but there is uncertainty over the use of out of office blood pressure measurements in stroke patients in guidelines. This is a study designed to establish the feasibility of a larger clinical trial, comparing home blood pressure monitoring, telemonitoring and medication titration with standard care. The study hypothesis is that home BP measurement and telemonitoring with medication titration may lead to improved BP control compared to standard of care clinical practice.
• Age ≥40
• Ischaemic stroke1, high-risk TIA, proven by imaging (brain CT/MRI)
• Living at home and independent (walking without the aid of another person, but may have some help for daily activities)
• SBP≥140mmHg at entry (average of 2 measures, seated, in the same arm, after resting alone in office for 10 minutes)
• Qualifying event between 30 days and 1 year of randomisation
• Glomerular filtration rate (eGFR) greater than or equal to 50ml/min/m2 (within 3 months of randomisation)
• Medically-stable and capable of participating in a randomised trial, including home BP measures, in the opinion of the study physician
• Willing to provide informed consent (no surrogate consent will apply)