FORAGER-2: A Phase 3, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Vepugratinib Combined With Enfortumab Vedotin and Pembrolizumab in Adults With Untreated Locally Advanced or Metastatic Urothelial Carcinoma With an FGFR3 Genetic Alteration
Status: Recruiting
Location: See all (273) locations...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to test a new medicine, vepugratinib, in comparison with placebo, to see if it is safe and can help people with a bladder cancer that is advanced or has spread. Vepugratinib or placebo will be administered in combination with enfortumab vedotin and pembrolizumab. Study participation could last up to approximately 6 years.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Have histologically confirmed, unresectable locally advanced or metastatic urothelial cancer (mUC). Individuals with mixed histology other than small cell or neuroendocrine carcinoma are eligible if a urothelial component is present.
• Have a qualifying fibroblast growth factor receptor 3 (FGFR3) genetic alteration determined via molecular testing from a tumor or blood sample obtained at or any time after diagnosis of advanced or metastatic urothelial cancer.
• Have measurable disease by investigator assessment defined by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
• Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2.
• Have adequate laboratory parameters
Locations
United States
Alabama
Clearview Cancer Institute
RECRUITING
Huntsville
Arizona
The University of Arizona Cancer Center - North Campus
NOT_YET_RECRUITING
Tucson
California
Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine
NOT_YET_RECRUITING
Irvine
TRIO-US (Translational Research in Oncology-US)
NOT_YET_RECRUITING
Los Angeles
UCLA Hematology/Oncology - Santa Monica
NOT_YET_RECRUITING
Los Angeles
University of California, Irvine (UCI) Health - UC Irvine Medical Center
NOT_YET_RECRUITING
Orange
University of California Davis (UC Davis) Comprehensive Cancer Center
NOT_YET_RECRUITING
Sacramento
UCSF Medical Center at Mission Bay
RECRUITING
San Francisco
Hunt Cancer Institute, an Affiliate of Cedars-Sinai Cancer (TMPN)
RECRUITING
Torrance
Colorado
AdventHealth Medical Group - Porter
NOT_YET_RECRUITING
Denver
Colorado West Healthcare System - Grand Valley Oncology
RECRUITING
Grand Junction
Florida
AdventHealth Orlando
NOT_YET_RECRUITING
Orlando
Idaho
St. Luke's Cancer Institute: Boise
NOT_YET_RECRUITING
Boise
Illinois
University of Chicago Medical Center
NOT_YET_RECRUITING
Chicago
University of Illinois at Chicago
NOT_YET_RECRUITING
Chicago
Indiana
Parkview Research Center at Parkview Regional Medical Center
NOT_YET_RECRUITING
Fort Wayne
Franciscan Health
NOT_YET_RECRUITING
Indianapolis
Indiana University Melvin and Bren Simon Cancer Center
RECRUITING
Indianapolis
Kentucky
University of Kentucky Chandler Medical Center
SUSPENDED
Lexington
Louisiana
Mary Bird Perkins Cancer Center
RECRUITING
Baton Rouge
Ochsner Clinic Foundation
NOT_YET_RECRUITING
New Orleans
Massachusetts
Massachusetts General Hospital
NOT_YET_RECRUITING
Boston
Maryland
Johns Hopkins Hospital
NOT_YET_RECRUITING
Baltimore
Michigan
Brigitte Harris Cancer Pavilion
NOT_YET_RECRUITING
Detroit
Karmanos Cancer Institute
NOT_YET_RECRUITING
Detroit
Missouri
Oncology Hematology Associates
NOT_YET_RECRUITING
Springfield
Washington University School of Medicine
RECRUITING
St Louis
North Carolina
Levine Cancer Institute
NOT_YET_RECRUITING
Charlotte
Oncology Specialists of Charlotte
NOT_YET_RECRUITING
Charlotte
Nevada
Comprehensive Cancer Centers of Nevada
RECRUITING
Las Vegas
New York
Columbia University Irving Medical Center
NOT_YET_RECRUITING
New York
Memorial Sloan Kettering Cancer Center
RECRUITING
New York
Weill Cornell Medical College
NOT_YET_RECRUITING
New York
Ohio
University of Cincinnati Medical Center
NOT_YET_RECRUITING
Cincinnati
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T
NOT_YET_RECRUITING
Columbus
Oregon
Kaiser Permanente Interstate Medical Office Central
RECRUITING
Portland
Oregon Health and Science University
NOT_YET_RECRUITING
Portland
Providence Portland Medical Center
NOT_YET_RECRUITING
Portland
Providence St. Vincent Medical Center
NOT_YET_RECRUITING
Portland
Pennsylvania
Lancaster General Hospital - Ann B Barshinger Cancer Institute
NOT_YET_RECRUITING
Lancaster
AHN Allegheny General Hospital
NOT_YET_RECRUITING
Pittsburgh
South Dakota
Avera Cancer Institute- Research
RECRUITING
Sioux Falls
Tennessee
Sarah Cannon Research Institute
NOT_YET_RECRUITING
Nashville
SCRI Oncology Partners
NOT_YET_RECRUITING
Nashville
Tennessee Oncology
RECRUITING
Nashville
Texas
USO-Texas Oncology-Central/South Texas
RECRUITING
Austin
World Research Link
RECRUITING
Baytown
Parkland Health and Hospital System
NOT_YET_RECRUITING
Dallas
UT Southwestern Medical Center
NOT_YET_RECRUITING
Dallas
University of Texas MD Anderson Cancer Center
NOT_YET_RECRUITING
Houston
Nova Oncology
RECRUITING
Mcallen
US Oncology Research Network
NOT_YET_RECRUITING
The Woodlands
USO - Texas Oncology - Northeast Texas
NOT_YET_RECRUITING
Tyler
Virginia
USO - Virginia Oncology Associates
NOT_YET_RECRUITING
Norfolk
Other Locations
Australia
Box Hill Hospital
NOT_YET_RECRUITING
Box Hill
Mater Misericordiae Limited
NOT_YET_RECRUITING
Brisbane
GenesisCare - Campbelltown
NOT_YET_RECRUITING
Campbelltown
Austin Health
NOT_YET_RECRUITING
Heidelberg
Macquarie University
NOT_YET_RECRUITING
Macquarie University
Sir Charles Gairdner Hospital
NOT_YET_RECRUITING
Perth
Prince of Wales Hospital
NOT_YET_RECRUITING
Randwick
Western Health-Sunshine & Footscray Hospitals
NOT_YET_RECRUITING
St Albans
Calvary Mater Newcastle
NOT_YET_RECRUITING
Waratah
Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
NOT_YET_RECRUITING
Barretos
CPAM - Centro de Pesquisas da Amazônia
NOT_YET_RECRUITING
Belém
Hospital Mario Penna
NOT_YET_RECRUITING
Belo Horizonte
Oncocentro de Minas Gerais
NOT_YET_RECRUITING
Belo Horizonte
Hospital Tacchini
NOT_YET_RECRUITING
Bento Gonçalves
Centro Integrado de Oncologia de Curitiba
NOT_YET_RECRUITING
Curitiba
IOP Pesquisa
NOT_YET_RECRUITING
Curitiba
Centro Paraibano De Oncologia - Oncoclínicas
NOT_YET_RECRUITING
João Pessoa
Hospital de Cancer de Londrina
NOT_YET_RECRUITING
Londrina
Liga Norte Riograndense Contra o Câncer
NOT_YET_RECRUITING
Natal
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
NOT_YET_RECRUITING
Porto Alegre
Hospital Nossa Senhora da Conceição
NOT_YET_RECRUITING
Porto Alegre
Hospital São Lucas da PUCRS
NOT_YET_RECRUITING
Porto Alegre
Instituto D'Or Pesquisa e Ensino
NOT_YET_RECRUITING
Rio De Janeiro
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA
NOT_YET_RECRUITING
Rio De Janeiro
Clinica Amo - Rio Vermelho
NOT_YET_RECRUITING
Salvador
Nucleo de Oncologia da Bahia
NOT_YET_RECRUITING
Salvador
Instituto de Oncologia Saint Gallen
NOT_YET_RECRUITING
Santa Cruz Do Sul
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
NOT_YET_RECRUITING
São Caetano Do Sul
Centro Paulista de Oncologia Clínica
NOT_YET_RECRUITING
São Paulo
Hospital Alemao Oswaldo Cruz
NOT_YET_RECRUITING
São Paulo
Hospital BP
NOT_YET_RECRUITING
São Paulo
IBCC - Núcleo de Pesquisa e Ensino
NOT_YET_RECRUITING
São Paulo
Icesp - Instituto Do Câncer Do Estado de São Paulo
NOT_YET_RECRUITING
São Paulo
Instituto do Cancer Arnaldo Vieira de Carvalho
NOT_YET_RECRUITING
São Paulo
Canada
Arthur J.E. Child Comprehensive Cancer Centre
NOT_YET_RECRUITING
Calgary
Hamilton Health Sciences-Juravinski Cancer Centre
NOT_YET_RECRUITING
Hamilton
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus
NOT_YET_RECRUITING
Québec
BC Cancer Vancouver
NOT_YET_RECRUITING
Vancouver
China
Beijing Cancer hospital
RECRUITING
Beijing
Beijing GoBroad Hospital
RECRUITING
Beijing
Peking University First Hospital
RECRUITING
Beijing
Peking University Third Hospital
RECRUITING
Beijing
The First Hospital of Jilin University
RECRUITING
Changchun
Hunan Cancer Hospital
NOT_YET_RECRUITING
Changsha
Xiangya Hospital Central South University
RECRUITING
Changsha
West China Hospital, Sichuan University
RECRUITING
Chengdu
Chongqing University Cancer Hospital
RECRUITING
Chongqing
The First Affiliated Hospital of Chongqing Medical University
RECRUITING
Chongqing
Sun Yat-Sen University Cancer Centre
RECRUITING
Guangzhou
The First Affiliated Hospital of Guangzhou Medical University
RECRUITING
Guangzhou
Zhujiang Hospital
RECRUITING
Guangzhou
Sir Run Run Shaw Hospital
RECRUITING
Hangzhou
Zhejiang Cancer Hospital
NOT_YET_RECRUITING
Hangzhou
Zhejiang Provincial People's Hospital
RECRUITING
Hangzhou
Harbin Medical University Cancer Hospital
NOT_YET_RECRUITING
Harbin
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
RECRUITING
Nanjing
Guangxi Medical University Affiliated Tumor Hospital
RECRUITING
Nanning
Ningbo First Hospital
RECRUITING
Ningbo
Huashan Hospital, Fudan University
RECRUITING
Shanghai
Renji Hospital Shanghai Jiao Tong University School of Medicine
RECRUITING
Shanghai
Shanghai Tenth People's Hospital
RECRUITING
Shanghai
The Second Hospital of Tianjin Medical University
RECRUITING
Tianjin
Tongji Hospital Tongji Medical,Science & Technology
RECRUITING
Wuhan
Denmark
Aalborg Universitetshospital, Syd
NOT_YET_RECRUITING
Aalborg
Aarhus Universitetshospital, Skejby
NOT_YET_RECRUITING
Aarhus
Herlev and Gentofte Hospital
NOT_YET_RECRUITING
Copenhagen
Rigshospitalet
NOT_YET_RECRUITING
Copenhagen
Næstved Sygehus
NOT_YET_RECRUITING
Næstved
France
Institut de Cancérologie de l'Ouest
NOT_YET_RECRUITING
Angers
CHU de Bordeaux Hop St ANDRE
NOT_YET_RECRUITING
Bordeaux
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
NOT_YET_RECRUITING
Bordeaux
CHRU de Brest
NOT_YET_RECRUITING
Brest
Centre François Baclesse
NOT_YET_RECRUITING
Caen
Centre Oscar Lambret
NOT_YET_RECRUITING
Lille
Centre Leon Berard
NOT_YET_RECRUITING
Lyon Cedex08
Institut Paoli-Calmettes
NOT_YET_RECRUITING
Marseille
Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carém -T
NOT_YET_RECRUITING
Nîmes
Centre Hospitalier Lyon Sud
NOT_YET_RECRUITING
Pierre-bénite
Oncopole Claudius Regaud
NOT_YET_RECRUITING
Toulouse
Gustave Roussy
NOT_YET_RECRUITING
Villejuif
Germany
Helios Klinikum Bad Saarow
NOT_YET_RECRUITING
Bad Saarow
Charité Universitaetsmedizin Berlin - Campus Mitte
NOT_YET_RECRUITING
Berlin
Evangelisches Krankenhaus Bielefeld - Johannesstift
NOT_YET_RECRUITING
Bielefeld
Johanniter-Krankenhaus
NOT_YET_RECRUITING
Bonn
Studienzentrum Bayenthal Urologische Partnerschaft Köln
NOT_YET_RECRUITING
Cologne
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
NOT_YET_RECRUITING
Dresden
Urologicum Duisburg Fachärztesozietät - Walsum
NOT_YET_RECRUITING
Duisburg
Universitaetsklinikum Duesseldorf
NOT_YET_RECRUITING
Düsseldorf
Universitaetsklinikum Erlangen
NOT_YET_RECRUITING
Erlangen
Universitaetsklinikum Essen
NOT_YET_RECRUITING
Essen
Krankenhaus Nordwest GmbH
NOT_YET_RECRUITING
Frankfurt
Universitaetsklinikum Freiburg
NOT_YET_RECRUITING
Freiburg Im Breisgau
Universitätsmedizin Greifswald
NOT_YET_RECRUITING
Greifswald
Universitaetsklinikum Hamburg-Eppendorf
NOT_YET_RECRUITING
Hamburg
NCT
NOT_YET_RECRUITING
Heidelberg
InVO Institut für Versorgungsforschung in der Onkologie
NOT_YET_RECRUITING
Koblenz
Universitätsklinikum Schleswig-Holstein
NOT_YET_RECRUITING
Lübeck
Klinikum Rechts Der Isar Der Technischen Universität München
NOT_YET_RECRUITING
Munich
Universitätsklinikum Münster - Albert Schweitzer Campus
NOT_YET_RECRUITING
Münster
Klinikum Nürnberg Nord
NOT_YET_RECRUITING
Nuremberg
Studienpraxis Urologie
NOT_YET_RECRUITING
Nürtingen
Universitätsmedizin Rostock
NOT_YET_RECRUITING
Rostock
Universitaetsklinikum Tuebingen
NOT_YET_RECRUITING
Tübingen
Universitaetsklinikum Ulm
NOT_YET_RECRUITING
Ulm
Universitaetsklinikum Wuerzburg
NOT_YET_RECRUITING
Würzburg
Hungary
Országos Onkológiai Intézet
NOT_YET_RECRUITING
Budapest
Semmelweis Egyetem
NOT_YET_RECRUITING
Budapest
Debreceni Egyetem Klinikai Kozpont
NOT_YET_RECRUITING
Debrecen
Szabolcs Szatmár Bereg Vármegyei Oktatókórház
NOT_YET_RECRUITING
Nyíregyháza
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
NOT_YET_RECRUITING
Szeged
Italy
Instituto Tumori Giovanni Paolo II
NOT_YET_RECRUITING
Bari
Fondazione IRCCS Istituto Nazionale dei Tumori
NOT_YET_RECRUITING
Milan
Ospedale San Raffaele
NOT_YET_RECRUITING
Milan
Azienda Ospedaliera Universitaria Federico II
NOT_YET_RECRUITING
Naples
Istituto Oncologico Veneto IRCCS
NOT_YET_RECRUITING
Padova
Azienda Ospedaliera Universitaria Pisana
NOT_YET_RECRUITING
Pisa
Fondazione Policlinico Universitario Agostino Gemelli
NOT_YET_RECRUITING
Roma
Istituto Nazionale Tumori Regina Elena
NOT_YET_RECRUITING
Rome
Japan
National Cancer Center Hospital
NOT_YET_RECRUITING
Chūōku
Kyushu University Hospital
NOT_YET_RECRUITING
Fukuoka
Hirosaki University Hospital
NOT_YET_RECRUITING
Hirosaki
Kanazawa University Hospital
NOT_YET_RECRUITING
Kanazawa
National Cancer Center Hospital East
NOT_YET_RECRUITING
Kashiwa
St. Marianna University Hospital
NOT_YET_RECRUITING
Kawasaki
Kagawa University Hospital
RECRUITING
Kita-ku
Kobe City Medical Center General Hospital
RECRUITING
Kobe
The Cancer Institute Hospital of JFCR
RECRUITING
Kōtoku
Kyoto University Hospital
NOT_YET_RECRUITING
Kyoto
National Hospital Organization Shikoku Cancer Center
NOT_YET_RECRUITING
Matsuyama
Aichi Cancer Center Hospital
NOT_YET_RECRUITING
Nagoya
Niigata University Medical & Dental Hospital
NOT_YET_RECRUITING
Niigata
Osaka International Cancer Institute
NOT_YET_RECRUITING
Osaka
Gunma Prefectural Cancer Center
RECRUITING
Otashi
Hokkaido University Hospital
RECRUITING
Sapporo
Tohoku University Hospital
NOT_YET_RECRUITING
Sendai
Iwate Medical University Hospital
RECRUITING
Shiwa-gun Yahaba-cho
Tokushima University Hospital
NOT_YET_RECRUITING
Tokushima
Tsukuba University Hospital
RECRUITING
Tsukuba
Netherlands
Amsterdam UMC, locatie VUmc
NOT_YET_RECRUITING
Amsterdam
Amphia Ziekenhuis, locatie Breda Molengracht
NOT_YET_RECRUITING
Breda
Radboudumc
NOT_YET_RECRUITING
Nijmegen
Erasmus Medisch Centrum
NOT_YET_RECRUITING
Rotterdam
Poland
IN VIVO
NOT_YET_RECRUITING
Bydgoszcz
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie
NOT_YET_RECRUITING
Koszalin
Pratia MCM Krakow
NOT_YET_RECRUITING
Krakow
AIDPORT Sp. z o.o.
NOT_YET_RECRUITING
Skórzewo
GYNCENTRUM Szpital
NOT_YET_RECRUITING
Sosnowiec
Luxmed Onkologia sp. z o. o.
NOT_YET_RECRUITING
Warsaw
Medical Concierge Centrum Medyczne
NOT_YET_RECRUITING
Warsaw
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
NOT_YET_RECRUITING
Warsaw
Szpital Grochowski im. dr med. Rafała Masztaka SPZOZ
NOT_YET_RECRUITING
Warsaw
Wojskowy Instytut Medyczny Państwowy Instytut Badawczy
NOT_YET_RECRUITING
Warsaw
WSD MEDI
NOT_YET_RECRUITING
Warsaw
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu
NOT_YET_RECRUITING
Wrocaw
Republic of Korea
National Cancer Center
NOT_YET_RECRUITING
Goyang-si
Chungnam national university hospital
RECRUITING
Junggu
Gachon University Gil Medical Center
RECRUITING
Namdong-gu
Seoul National University Bundang Hospital
RECRUITING
Seongnam
Asan Medical Center
NOT_YET_RECRUITING
Seoul
Ewha Womans University Mokdong Hospital
RECRUITING
Seoul
Samsung Medical Center
RECRUITING
Seoul
Seoul National University Hospital
RECRUITING
Seoul
Severance Hospital, Yonsei University Health System
RECRUITING
Seoul
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING
Seoul
Spain
Hospital Infanta Cristina
NOT_YET_RECRUITING
Badajoz
Institut Català d'Oncologia (ICO) - Badalona
NOT_YET_RECRUITING
Badalona
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces
NOT_YET_RECRUITING
Barakaldo
Hospital Clínic de Barcelona
NOT_YET_RECRUITING
Barcelona
Hospital de la Santa Creu i Sant Pau
NOT_YET_RECRUITING
Barcelona
Hospital Universitari Vall d'Hebron
NOT_YET_RECRUITING
Barcelona
Hospital Universitario Reina Sofia
NOT_YET_RECRUITING
Córdoba
Hospital General Universitario de Elche
NOT_YET_RECRUITING
Elche
Institut Català d'Oncologia (ICO) - Girona
NOT_YET_RECRUITING
Girona
Instituto Catalan de Oncologia - Hospital Duran i Reynals
NOT_YET_RECRUITING
Hospitalet
Hospital Insular de Gran Canaria
NOT_YET_RECRUITING
Las Palmas De Gran Canaria
Hospital Clinico San Carlos
NOT_YET_RECRUITING
Madrid
Hospital General Universitario Gregorio Marañon
NOT_YET_RECRUITING
Madrid
Hospital La Princesa
NOT_YET_RECRUITING
Madrid
Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING
Madrid
Hospital Universitario La Paz
NOT_YET_RECRUITING
Madrid
Hospital Universitario Ramón y Cajal
NOT_YET_RECRUITING
Madrid
MD Anderson Cancer Center
NOT_YET_RECRUITING
Madrid
H.R.U Málaga - Hospital General
NOT_YET_RECRUITING
Málaga
Complejo Hospitalario de Navarra
NOT_YET_RECRUITING
Pamplona
Hospital Universitario Quironsalud Madrid
NOT_YET_RECRUITING
Pozuelo De Alarcón
Hospital Universitari Sant Joan de Reus
NOT_YET_RECRUITING
Reus
Hospital Universitario Marqués de Valdecilla
NOT_YET_RECRUITING
Santander
CHUS - Hospital Clinico Universitario
NOT_YET_RECRUITING
Santiago De Compostela
Hospital Universitario Virgen Del Rocio
NOT_YET_RECRUITING
Seville
Hospital Arnau de Vilanova
NOT_YET_RECRUITING
Valencia
Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING
Kaohsiung City
Chang Gung Memorial Hospital at Kaohsiung
NOT_YET_RECRUITING
Kaohsiung Niao Sung Dist
China Medical University Hospital
NOT_YET_RECRUITING
Taichung
Taichung Veterans General Hospital
NOT_YET_RECRUITING
Taichung
Chi Mei Hospital - Liouying Branch
NOT_YET_RECRUITING
Tainan
Chi Mei Medical Center
NOT_YET_RECRUITING
Tainan
National Cheng Kung University Hospital
NOT_YET_RECRUITING
Tainan
National Taiwan University Cancer Center (NTUCC)
NOT_YET_RECRUITING
Taipei
National Taiwan University Hospital
RECRUITING
Taipei
Taipei Veterans General Hospital
NOT_YET_RECRUITING
Taipei
Chang Gung Medical Foundation-Linkou Branch
NOT_YET_RECRUITING
Taoyuan District
Turkey
Adana Medical Park Seyhan Hastanesi
NOT_YET_RECRUITING
Adana
Sakarya University School of Medicine
NOT_YET_RECRUITING
Adapazarı
Ankara Bilkent Şehir Hastanesi
NOT_YET_RECRUITING
Ankara
Ankara University Health Practice and Research Hospitals
NOT_YET_RECRUITING
Ankara
Antalya Egitim ve Arastırma Hastanesi
NOT_YET_RECRUITING
Antalya
Dicle Üniversitesi
NOT_YET_RECRUITING
Diyarbakır
Trakya University
NOT_YET_RECRUITING
Edirne
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
NOT_YET_RECRUITING
Gaziantep
Marmara Universitesi Pendik Egitim Arastirma Hastanesi
NOT_YET_RECRUITING
Istanbul
zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi
NOT_YET_RECRUITING
Izmir
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
NOT_YET_RECRUITING
Kadıköy
United Kingdom
Huddersfield Royal Infirmary
NOT_YET_RECRUITING
Huddersfield
Royal Marsden Hospital (Chelsea)
NOT_YET_RECRUITING
London
Royal Marsden Hospital (Sutton)
NOT_YET_RECRUITING
London
St Bartholomew's Hospital
NOT_YET_RECRUITING
London
University College London Hospital
NOT_YET_RECRUITING
London
The Christie NHS Foundation Trust
NOT_YET_RECRUITING
Manchester
Weston Park Hospital
NOT_YET_RECRUITING
Sheffield
Contact Information
Primary
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
LillyTrials@Lilly.com
1-317-615-4559
Backup
Physicians interested in becoming principal investigators please contact
clinical_inquiry_hub@lilly.com
Time Frame
Start Date: 2025-12-12
Estimated Completion Date: 2033-05
Participants
Target number of participants: 450
Treatments
Experimental: Vepugratinib + EV + Pembrolizumab (Safety Lead In)
Vepugratinib administered orally with EV + pembrolizumab administered IV
Experimental: Vepugratinib + Enfortumab Vedotin (EV) + Pembrolizumab
Vepugratinib administered orally, and EV + pembrolizumab administered by intravenous (IV) infusion.
Placebo_comparator: Placebo + EV + Pembrolizumab
Placebo administered orally, and EV + pembrolizumab administered by IV infusion.
Related Therapeutic Areas
Sponsors
Leads: Eli Lilly and Company