Proteomic and Metabolomic Detection and Analysis of Serum from Patients with Acute Severe Traumatic Brain Injury: a Prospective, Multicentered Study
The goal of this experimental observation study is to figure out differently expressed biomarkers in serum in traumatic brain injury patients, compared with bone fracture patients. The main questions it aims to answer are: 1. Which proteins and metabolites are differently expressed in TBI patients' serum? 2. Which proteins or metabolites can serve as the new serum biomarkers for diagnosing TBI? Participants will be treated by routine treatments, and their serum samples will be collected in the emergency room.
• With cerebral contusion in 24Hrs for case group, or with traumatic bone fracture in 24Hrs for control group.
• The Glasglow Coma Scale ranges in 3-8 for case group.
• Need to have routine laboratory examination of blood sample.
• Patients or agents sign the informed consent.