CorMatrix® Cor™ TRICUSPID ECM® Valve Replacement Study

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this pivotal study is to demonstrate the safety and performance of the Cor TRICUSPID ECM (extracellular matrix) Valve (or Cor PEDIATRIC Tricuspid ECM Valve) for the surgical management of tricuspid valve disease and dysfunction in adult and pediatric patients. The main question(s) it aims to answer are: * whether the device may be implanted successfully and safely, and * whether the device effectively treats tricuspid valve disease and dysfunction through 12 months Participants will undergo: * preoperative evaluation * tricuspid valve replacement with the Cor TRICUSPID ECM Valve * postoperative evaluation, including at hospital discharge, 30 days, 6 months, and 12 months, and then annually thereafter through 5 years

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Patient with a regurgitant or absent tricuspid valve requiring surgical treatment including those patients having concomitant cardiac procedures

• Patient/authorized legal guardian understands the nature of the procedure, is willing to comply with associated follow-up evaluations, and provides written informed consent and the pediatric patient (if applicable) provides written assent (if able) prior to procedure

• Patient/patient's authorized legal guardian is geographically stable (or willing to return for required study follow-up) and understands and is willing to fulfill all of the expected requirements of this clinical protocol

• Patients where the Cor TRICUSPID ECM Valve will be the physiological right-sided atrioventricular (AV) valve

Locations
United States
Indiana
St Francis Hospital
RECRUITING
Indianapolis
New York
Columbia University Irving Medical Center/New York Presbyterian
RECRUITING
New York
Contact Information
Primary
Robert G Matheny, MD
Rmatheny@Cormatrix.com
404-276-7777
Backup
Brad Solberg, MBA
brad@experiengroup.com
4084644001
Time Frame
Start Date: 2022-08-10
Estimated Completion Date: 2026-12
Participants
Target number of participants: 92
Treatments
Other: Group A: Adults treated with SIS 1.0 Cor TRICUSPID ECM Valve
Adults (\>/= 21 years of age) treated with the SIS 1.0 Cor TRICUSPID ECM Valve
Other: Group B: Pediatrics treated with SIS 1.0 Cor TRICUSPID ECM Valve
Pediatrics (\<21 years of age) treated with SIS 1.0 Cor TRICUSPID ECM Valve
Other: Group C: Adults treated with SIS 2.0 Cor TRICUSPID ECM Valve
Adults (\>/= 21 years of age) treated with the SIS 2.0 Cor TRICUSPID ECM Valve
Other: Group D: Pediatrics treated with SIS 2.0 Cor TRICUSPID ECM Valve
Pediatrics (\<21 years of age) treated with SIS 2.0 Cor TRICUSPID ECM Valve
Related Therapeutic Areas
Sponsors
Collaborators: Yale University
Leads: CorMatrix Cardiovascular, Inc.

This content was sourced from clinicaltrials.gov