Early Feasibility Study (EFS) of the 'Pivot Extend' in Treatment for Tricuspid Regurgitation (SPACER Study)

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This clinical trial aims to evaluate the safety and demonstrate the efficacy of treatment to improve tricuspid regurgitation (TR) symptoms in patients with severe and clinically symptomatic TR through long-term implantation of an investigational medical device. 1. Determine the safety of long-term implantation of the investigational medical device Pivot Extend by monitoring for MACEs associated with the investigational medical device or procedure that may occur with long-term associated with the investigational medical device or procedure that may occur with long-term implantation. 2. Device success, procedural success, and clinical outcomes of long-term implantation of the investigational medical device Pivot Extend will be monitored.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adults 18 years of age or older at the time of screening

• Those with symptoms despite medical therapy (OMT, diuretics/medications) for TR for at least 1 month at screening

• Those who meet the criteria of severe (3+) or worse on the TR grade classification table on echocardiography performed at the screening visit

• Those with clinical symptoms of New York Heart Association (NYHA) class 2 or worse

• Those deemed suitable for percutaneous valve intervention by a Heart Team that includes at least one cardiologist, one cardiac surgeon and one anesthesiologist.

• Those who have voluntarily decided to participate in this clinical trial and have provided written informed consent

• Those who can understand and follow the investigator's instructions and are able to participate for the entire duration of the study

Locations
Other Locations
Georgia
Israeli-Georgian Medical Research Clinic Healthycore
RECRUITING
Tbilisi
Tbilisi Heart and Vascular Clinic
RECRUITING
Tbilisi
Tbilisi Heart Center
RECRUITING
Tbilisi
Contact Information
Primary
Markus Reinthaler, MD, PhD
reinthal@gmail.com
+49 (0) 157 37972007
Backup
Seung-Whan Lee, MD, PhD
seungwlee@amc.seoul.kr
+82 1688-7575
Time Frame
Start Date: 2025-05
Estimated Completion Date: 2026-12
Participants
Target number of participants: 7
Treatments
Experimental: Treatment to Improve TR Symptoms with Investigational Medical Device Implantation
Participants assigned to this arm will receive an investigational medical device designed to improve symptoms of severe and clinically symptomatic tricuspid regurgitation (TR). Following device implantation, participants will be monitored in a specialized facility for at least 24 hours with real-time observation of vital signs. The device's safety and efficacy will be assessed over 12 months through scheduled visits, with clinical progress monitored throughout. Device removal may be performed if adverse events occur or if deemed necessary by the investigator.
Related Therapeutic Areas
Sponsors
Leads: Tau-MEDICAL Co., Ltd.

This content was sourced from clinicaltrials.gov