TrimethylaminuriaSymptoms, Doctors, Treatments, Advances & More
Trimethylaminuria Overview
Learn About Trimethylaminuria
Trimethylaminuria is a disorder in which the body is unable to break down trimethylamine, a chemical compound that has a pungent odor. Trimethylamine has been described as smelling like rotten or decaying fish. As this compound builds up in the body, it causes affected people to give off a strong fishy odor in their sweat, urine, and breath. The intensity of the odor may vary over time. The odor can interfere with many aspects of daily life, affecting a person's relationships, social life, and career. Some people with trimethylaminuria experience depression and social isolation as a result of this condition.
Variants (also known as mutations) in the FMO3 gene cause trimethylaminuria. This gene provides instructions for making an enzyme that breaks down nitrogen-containing compounds from the diet, including trimethylamine. This compound is produced by bacteria in the intestine during the digestion of eggs, liver, legumes (such as soybeans and peas), certain kinds of fish, and other foods. Normally, the FMO3 enzyme converts strong-smelling trimethylamine into another molecule that has no odor. If the enzyme is missing or its activity is reduced because of a variant in the FMO3 gene, trimethylamine is not processed properly and can build up in the body. As excess trimethylamine is released in a person's sweat, urine, and breath, it causes the odor characteristic of trimethylaminuria. Researchers believe that stress and diet also play a role in triggering symptoms.
Trimethylaminuria is an uncommon genetic disorder; its incidence is unknown.
Most cases of trimethylaminuria appear to be inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have variants. Most often, the parents of an individual with an autosomal recessive condition each carry one copy of the altered gene, but typically do not show signs and symptoms of the condition. Carriers of an FMO3 variant, however, may have mild symptoms of trimethylaminuria or experience temporary episodes of strong body odor.
Hiroshi Yamazaki practices practicing medicine in Tokyo, Japan. Mr. Yamazaki is rated as an Elite expert by MediFind in the treatment of Trimethylaminuria. He is also highly rated in 1 other condition, according to our data. His clinical expertise encompasses Trimethylaminuria, Tongue Cancer, Microcephalic Osteodysplastic Primordial Dwarfism Type 1 (MOPD1), Endoscopy, and Angioplasty.
Professional Health Care Of Pinellas LLC
Hazem Al is a primary care provider, practicing in Internal Medicine in Pinellas Park, Florida. Dr. Al is rated as a Distinguished provider by MediFind in the treatment of Trimethylaminuria. He is also highly rated in 167 other conditions, according to our data. His clinical expertise encompasses Necrosis, Peptic Ulcer, Pneumonia, Gastrostomy, and Endoscopy. Dr. Al is board certified in American Board Of Internal Medicine. Dr. Al is currently accepting new patients.
Concetta Scimone practices practicing medicine in Messina, Italy. Ms. Scimone is rated as a Distinguished expert by MediFind in the treatment of Trimethylaminuria. She is also highly rated in 7 other conditions, according to our data. Her clinical expertise encompasses Trimethylaminuria, Cerebral Cavernous Malformation, Hemangioma, and Retinopathy Pigmentary Mental Retardation.
Summary: CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, in...
Published Date: September 08, 2021
Published By: National Institutes of Health