What is the definition of Tumefactive Multiple Sclerosis?
Tumefactive multiple sclerosis is characterized by a tumor-like lesion larger than two centimeters and signs and symptoms similar to those of a brain tumor. It is a rare form of multiple sclerosis (MS). Symptoms of tumefactive MS often differ from other MS cases and may include, headaches, changes in thinking, confusion, speech problems, seizures, and weakness. The cause of tumefactive MS is not known. It often develops into the relapsing-remitting form of MS. In other cases there is only one occurrence of the condition. In still others the disease process remains less clear. While there is no cure for tumefactive MS, treatments such as corticosteroids are available to decrease disease activity.
What are the alternative names for Tumefactive Multiple Sclerosis?
- Diffuse cerebral sclerosis of Schilder
- Concentric demyelination
- Balo's concentric sclerosis
- Marburg variant
- Balo disease
- Baló concentric sclerosis
- Balo's disease
- Encephalitis periaxialis concentrica
What are the current treatments for Tumefactive Multiple Sclerosis?
date there have been no controlled treatment studies for tumefactive
multiple sclerosis. As a result, treatment decisions are largely based
on a doctor's experience and information from single case reports.
In a small number of cases, people with tumefactive multiple sclerosis
have minimal to no symptoms. A reasonable approach of care in these
cases is to monitor without treatment.
In most cases the
size of the lesion and resulting symptoms prompts treatment with
corticosteroids. As with other forms of multiple sclerosis,
corticosteroids (for example, intravenous methylprednisolone) should be the first
line of treatment. If corticosteroids are not effective, plasma exchange is tried. Another second line treatment that has been tried
with some success is Rituximab.