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Learn About Howel-Evans Syndrome

What is the definition of Howel-Evans Syndrome?
Tylosis with esophageal cancer (TOC) is an inherited condition that increases the risk for esophageal cancer. The symptoms of TOC include thickening of the skin on the palms and soles of the feet (palmoplantar keratoderma) and white lesions inside the mouth. People with TOC are at very high risk to develop esophageal cancer. The palmoplantar keratoderma usually occurs in childhood, and esophageal cancer usually occurs in adulthood. TOC is caused by a variant in the RHBDF2 gene and is inherited in an autosomal dominant pattern. Diagnosis is based on the symptoms, clinical exam, and family history. The diagnosis may be confirmed by the results of genetic testing.
What are the alternative names for Howel-Evans Syndrome?
  • Tylosis with esophageal cancer
  • Bennion-Patterson syndrome
  • Howel-Evans syndrome
  • Howell-Evans syndrome
  • Keratosis palmaris et plantaris with esophageal cancer
  • Keratosis palmoplantaris with esophageal cancer
  • Keratosis palmoplantaris-esophageal carcinoma syndrome
  • Palmoplantar hyperkeratosis-esophageal carcinoma syndrome
  • Palmoplantar keratoderma-esophageal carcinoma syndrome
  • TOC
  • Tylosis - oesophageal carcinoma
  • Tylosis-oesophageal carcinoma syndrome
Who are the top Howel-Evans Syndrome Local Doctors?
Marina Bravin
Advanced in Howel-Evans Syndrome
Dermatology
Advanced in Howel-Evans Syndrome
Dermatology

Bassett Oneonta Specialty Services

1 Associate Drive, 
Oneonta, NY 
Languages Spoken:
English

. Dr. Bravin is rated as an Advanced provider by MediFind in the treatment of Howel-Evans Syndrome. Her top areas of expertise are Actinic Keratosis, Melanoma, Warts, and Psoriasis.

Jennifer O'reilly
Experienced in Howel-Evans Syndrome
Internal Medicine
Experienced in Howel-Evans Syndrome
Internal Medicine

Bassett Health Center Norwich

55 Calvary Drive, 
Norwich, NY 
Languages Spoken:
English

. Dr. O'reilly is rated as an Experienced provider by MediFind in the treatment of Howel-Evans Syndrome. Her top areas of expertise are Ringworm, Maturity Onset Diabetes of the Young, Familial Hypertension, and Hypertension.

 
 
 
 
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Robert W. Petrie
Experienced in Howel-Evans Syndrome
Family Medicine
Experienced in Howel-Evans Syndrome
Family Medicine

Texas Health Family Care

6100 Lake Worth Boulevard, 
Fort Worth, TX 
Experience:
10+ years
Languages Spoken:
English

Robert Petrie is a primary care provider, practicing in Family Medicine in Fort Worth, Texas. Dr. Petrie has been practicing medicine for over 10 years and is rated as an Experienced provider by MediFind in the treatment of Howel-Evans Syndrome. His top areas of expertise are Obesity, Obesity in Children, High Cholesterol, and Hypertension.

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center