Effect of Changes in Carbohydrate Intake Patterns on Glucose Control in Patients with Type 1 Diabetes

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The blood glucose fluctuates greatly in T1DM patients, especially in the middle and late stages of the disease, and carbohydrate (CHO) is the main determinant of postprandial glucose response (PGR). Based on the previous investigation to understand how nutritional habits affect blood glucose control, we will conduct dietary intervention studies in T1DM patients to explore whether the adjustment of dietary pattern is beneficial to blood glucose control, and further explore the relevant mechanism through the detection of related metabolic indicators.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:

• Those who agree to participate in the study and sign informed consent;

• Diagnosis of type 1 diabetes mellitus (ADA2024);

• Age of 18\

⁃ 70 years;

• Dependent on exogenous insulin therapy, the treatment plan remains unchanged within 2 months (the type of insulin cannot be changed, and the dose can be adjusted according to plasma glucose);

• Body mass index (BMI) of 18\

⁃ 25kg/m2;

• HbA1c ≤11%;

Locations
Other Locations
China
First Affiliated Hospital, Nanjing Medical University
RECRUITING
Nanjing
Contact Information
Primary
Tao Yang, MD/PhD
yangt@njmu.edu.cn
86-25-83718836
Time Frame
Start Date: 2024-08-15
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 80
Treatments
Experimental: diverse carbohydrate diet
Carbohydrate provides 45\~55% of total dietary energy, protein 15\~20%, and fat 25 \~35%. Among them, 45\~50% of carbohydrate supply sources are refined grains, 45\~50% of carbohydrate supply sources are whole grains or beans.~The total energy is divided into 3 meals per day. The breakfast provides 25\~30% of total energy, lunch 30\~40%,and dinner 30\~35%.
Other: middle carbohydrate diet
Carbohydrate provides 45\~55% of total dietary energy, protein 15\~20%, and fat 25\~35%. 90\~95% of the carbohydrate supply comes from refined grains.~The total energy is divided into 3 meals per day. The breakfast provides 25\~30% of total energy, lunch 30\~40%,and dinner 30\~35%.
Related Therapeutic Areas
Sponsors
Leads: Yang Tao

This content was sourced from clinicaltrials.gov