Metabolic and Inflammatory Outcomes of the Ketogenic Diet Comparing Saturated and Unsaturated Fat Sources
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this clinical trial is to compare a healthy KETO diet supplemented with canola oil (KETO-Can) compared to a traditional KETO diet high in saturated fat (KETO-Sat) and low-fat diet (LFD) in adults at high risk of or diagnosed with type 2 diabetes. The main question\[s\] it aims to answer are: * Effects on CVD risk factors (plasma cholesterol, TG, ApoB100, glucose, insulin and HbA1C). * Effects on systemic inflammation and immune function. * Adherence to interventions. Participants will be randomized into 1 of the dietary treatments during which they will follow a Keto or a low-fat diet. Comparisons among groups at 3 and 6 months of intervention will be conducted.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Having overweight or obesity and HbA1C ≥ 5.7% at screening
Locations
Other Locations
Canada
University of Alberta
RECRUITING
Edmonton
Contact Information
Primary
Paulina Blanco Cervantes, MSc
blancoce@ualberta.ca
7804929506
Time Frame
Start Date: 2023-09-18
Estimated Completion Date: 2026-05-31
Participants
Target number of participants: 175
Treatments
Experimental: KETO-Can
KETO diet supplemented with Canola oil (high in MUFA and omega-3 FA).
Experimental: KETO-Sat
KETO diet supplemented with butter and coconut oil (high in SFA).
Active_comparator: Low fat diet (LFD)
Low fat diet supplemented with whole grain foods (pasta or brown rice) and oatmeal.
Related Therapeutic Areas
Sponsors
Leads: University of Alberta