Effect of Insulin and Insulin Pulses on Fasting Glucagon Secretion and on Glucose Metabolism in Subjects Without Type 2 Diabetes
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Maximum Age: 65
Healthy Volunteers: t
View:
• people with normal or impaired fasting glucose and normal or impaired glucose tolerance
Locations
United States
Minnesota
Mayo Clinic in Rochester
RECRUITING
Rochester
Contact Information
Primary
Kim Osmundson, CCRP
Osmundson.Kimberly@mayo.edu
507-255-0907
Backup
Jeanette Laugen
Laugen.Jeanette@mayo.edu
507-255-8110
Time Frame
Start Date: 2024-09-15
Estimated Completion Date: 2027-09-01
Participants
Target number of participants: 60
Treatments
Active_comparator: Intralipid and heparin
Between 0600 (-180 min) and 1300 (240 min) Intralipid (20%, 0.011ml/kg/min; Baxter, Healthcare, Deerfield, IL) and heparin (200 units prime, 0.2 unit/kg/min continuous) will be infused to induce acute insulin resistance.
Placebo_comparator: Saline
Between 0600 (-180 min) and 1300 (240 min) saline will be infused
Related Therapeutic Areas
Sponsors
Leads: Mayo Clinic