Type 2 Diabetes (T2D) Clinical Trials

• Legal age of consent and at least 18 years old

• Study 1 -

‣ BMI ≥ 30 kg/m2 or

⁃ 25 kg/m2 ≤ BMI \< 30 kg/m2 with at least one of the following weight-related comorbidities:

⁃ Hypertension

⁃ Prediabetes

⁃ Dyslipidemia

⁃ Cardiovascular disease

⁃ Obstructive sleep apnea.

• Study 2 - BMI ≥ 25 kg/m2 and T2DM defined as below:

‣ Established diagnosis of T2DM

⁃ Without established diagnosis of T2DM and HbA1c ≥ 6.5% (48 mmol/mol) at the screening visit

• Stable body weight (self-reported or documented) for 90 days prior to the screening visit (± 5% body weight change)

• History of at least one self-reported unsuccessful dietary effort to lose body weight.