Brown Adipose Tissue Activation by Spinal Cord Stimulation
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The objective of this study is to investigate and utilize spinal cord stimulation (SCS) as an effective approach to eliciting weight loss and potentially alleviating Type 2 diabetes mellitus (DM), as evidenced by increasing metabolism of adipose tissue.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 70
Healthy Volunteers: f
View:
• Age: 21-70 years
• Persistent neuropathic leg and back pain
• Subjects who are already planning to undergo SCS for pain
• Subjects who have not received a prior SCS trial for pain
• Subjects with a BMI of 25-45, using formula; weight (lb) / \[height (in)\]2 x 703
Locations
United States
Oregon
Oregon Health & Science University
RECRUITING
Portland
Contact Information
Primary
Kim Burchiel, MD
burchiek@ohsu.edu
503-494-4314
Time Frame
Start Date: 2021-02-19
Estimated Completion Date: 2026-10
Participants
Target number of participants: 10
Treatments
Experimental: All subjects
All subjects will have two PET/CT scans on days 3 and 5 after SCS electrode implantation: (1) Baseline and (2) SCS-activated. Other than SCS activation, both studies will be conducted under identical conditions. For the first scan, subjects will be randomly assigned to either a baseline (no SCS during PET/CT) or with SCS during PET/CT prior to the day of their first scan. The second scan will complete the sequence with either a baseline or SCS-activated scan, as randomized.
Related Therapeutic Areas
Sponsors
Leads: Oregon Health and Science University