A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, and Type 2 Diabetes
Status: Recruiting
Location: See all (153) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Have type 2 diabetes
• Are on stable treatment for type 2 diabetes for at least 90 days prior to screening
• Have a BMI ≥ 27 kg/m2
• Have a stable body weight (\<5% body weight change) for 90 days prior to screening
Locations
United States
Alabama
Birmingham Clinical Research
RECRUITING
Birmingham
Cullman Clinical Trials
RECRUITING
Cullman
Arizona
Tucson Clinical Research Institute
RECRUITING
Tucson
California
San Fernando Valley Health Institute
RECRUITING
Canoga Park
AMCR Institute
RECRUITING
Escondido
NorCal Medical Research, Inc
RECRUITING
Greenbrae
Ark Clinical Research
RECRUITING
Long Beach
Pacific Clinical Studies
RECRUITING
Los Alamitos
Inglewood Clinical
RECRUITING
Los Angeles
Care Access - Santa Clarita
RECRUITING
Santa Clarita
Encompass Clinical Research
RECRUITING
Spring Valley
Diablo Clinical Research, Inc.
RECRUITING
Walnut Creek
Colorado
Care Access - Aurora
RECRUITING
Aurora
Connecticut
New England Research Associates, LLC
RECRUITING
Bridgeport
CMR of Greater New Haven, LLC
RECRUITING
Hamden
Florida
Arrow Clinical Trials
RECRUITING
Daytona Beach
Care Access - Delray Beach
RECRUITING
Delray Beach
Fleming Island Center for Clinical Research
RECRUITING
Fleming Island
Nature Coast Clinical Research - Inverness
RECRUITING
Inverness
Jacksonville Center for Clinical Research
RECRUITING
Jacksonville
Flourish Research Acquisition, LLC dba Flourish Research - North Miami
RECRUITING
Miami
New Horizon Research Center
RECRUITING
Miami
Adult Medicine of Lake County, Inc.
RECRUITING
Mt. Dora
American Research Centers of Florida
RECRUITING
Pembroke Pines
Clinical Site Partners, LLC dba Flourish Research
RECRUITING
Winter Park
Georgia
Teak Research Consults - Dunwoody
RECRUITING
Dunwoody
Teak Research Consults
RECRUITING
Lawrenceville
The Jones Center Clinical Research
RECRUITING
Macon
Hawaii
Pacific Diabetes & Endocrine Center
RECRUITING
Honolulu
Illinois
NorthShore University Health System
RECRUITING
Skokie
Indiana
DM Clinical Research - Indianapolis
RECRUITING
Indianapolis
Louisiana
Clinical Trials Management, LLC d/b/a Flourish Research
RECRUITING
Metairie
IMA Clinical Research Monroe - Armand
RECRUITING
Monroe
Massachusetts
Lucida Clinical Trials
RECRUITING
New Bedford
Maryland
Centennial Medical Group
RECRUITING
Columbia
Missouri
Clinical Research Professionals
RECRUITING
Chesterfield
Clinvest Headlands Llc
RECRUITING
Springfield
North Carolina
PharmQuest Life Sciences, LLC
RECRUITING
Greensboro
West Clinical Research
RECRUITING
Morehead City
Trial Management Associates - Wilmington - Floral Parkway
RECRUITING
Wilmington
North Dakota
Lillestol Research
RECRUITING
Fargo
New Jersey
Hypertension & Nephrology Association
RECRUITING
Eatontown
IMA Clinical Research Warren
RECRUITING
Warren Township
New Mexico
Albuquerque Clinical Trials, Inc.
RECRUITING
Albuquerque
New York
NYC Research INC
RECRUITING
Long Island City
Ohio
Care Access - Lima
RECRUITING
Lima
Oregon
Summit Headlands
RECRUITING
Portland
Pennsylvania
Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair
RECRUITING
Pittsburgh
Preferred Primary Care Physicians
RECRUITING
Uniontown
South Carolina
Accellacare - Mt Pleasant
RECRUITING
Mt. Pleasant
Texas
IMA Clinical Research Austin
RECRUITING
Austin
Private Practice - Dr. Osvaldo A. Brusco
RECRUITING
Corpus Christi
Velocity Clinical Research, Dallas
RECRUITING
Dallas
Diabetes and Thyroid Center of Ft. Worth
RECRUITING
Fort Worth
Juno Research
RECRUITING
Houston
Southern Endocrinology Associates
RECRUITING
Mesquite
Research Your Health
RECRUITING
Plano
IMA Clinical Research San Antonio
RECRUITING
San Antonio
Utah
Ogden Clinic - Canyon View
RECRUITING
Ogden
Diabetes & Endocrine Treatment Specialists
RECRUITING
Sandy City
Other Locations
Argentina
Asociación de Beneficencia Hospital Sirio Libanés
NOT_YET_RECRUITING
Buenos Aires
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
NOT_YET_RECRUITING
Buenos Aires
Investigaciones Medicas Imoba Srl
NOT_YET_RECRUITING
Buenos Aires
Stat Research S.A.
NOT_YET_RECRUITING
Buenos Aires
Instituto Centenario
NOT_YET_RECRUITING
Caba
Centro Diabetológico Dr. Waitman
NOT_YET_RECRUITING
Córdoba
Centro de Investigaciones Clínicas Baigorria
NOT_YET_RECRUITING
Granadero Baigorria
Fundacion Estudios Clinicos
NOT_YET_RECRUITING
Rosario
Instituto Médico Catamarca IMEC
NOT_YET_RECRUITING
Rosario
China
Beijing Pinggu District Hospital
RECRUITING
Beijing
Luhe Hospital
RECRUITING
Beijing
Peking University People's Hospital
RECRUITING
Beijing
Sichuan Provincial People's Hospital
RECRUITING
Chengdu
The Second Affiliated Hospital Chongqing Medical University
RECRUITING
Chongqing
Zhujiang Hospital
RECRUITING
Guangzhou
The Second People's Hospital of Hefei
RECRUITING
Hefei
Jinan Central Hospital
RECRUITING
Jinan
The First Affiliated Hospital of Henan University of Science &Technology
RECRUITING
Luoyang Shi
Jiangxi Provincial People's Hospital
RECRUITING
Nanchang
Jiangsu Province Official Hospital
RECRUITING
Nanjing
Nanjing First Hospital
RECRUITING
Nanjing
The Second Affiliated Hospital of Nanjing Medical University
RECRUITING
Nanjing
Jiading District Central Hospital
RECRUITING
Shanghai
The Second Hospital of Tianjin Medical University
RECRUITING
Tianjin
Zigong First People's Hospital
RECRUITING
Zigong
Germany
Diabetespraxis Dr. Braun
ACTIVE_NOT_RECRUITING
Berlin
Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann
ACTIVE_NOT_RECRUITING
Bünde
InnoDiab Forschung Gmbh
ACTIVE_NOT_RECRUITING
Essen
Diabetes Zentrum Wilhelmsburg
ACTIVE_NOT_RECRUITING
Hamburg
Institut für Diabetesforschung GmbH Münster
ACTIVE_NOT_RECRUITING
Münster
Schwerpunktpraxis für Diabetes und Ernährungsmedizin Dr. med. Winfried Keuthage
ACTIVE_NOT_RECRUITING
Münster
RED-Institut GmbH
ACTIVE_NOT_RECRUITING
Oldenburg
India
Life Care Hospital and Research Centre
SUSPENDED
Bangalore
Belagavi Institute of Medical Sciences - Belagavi
SUSPENDED
Belgavi
Dr. Ram Manohar Lohia Institute of Medical Sciences
SUSPENDED
Lucknow
All India Institute of Medical Sciences (AIIMS) - Nagpur
SUSPENDED
Nagpur
Lifepoint Multispeciality Hospital
SUSPENDED
Pune
Ashirwad Hospital and Research Centre
SUSPENDED
Ulhasnagar
Japan
Hayashi Diabetes Internal Medicine Clinic
RECRUITING
Chigasaki
Tokyo-Eki Center-building Clinic
RECRUITING
Chūōku
Shonan Takai Clinic
RECRUITING
Kamakura
Oishi Clinic
RECRUITING
Kasuya-gun
OHAMA Diabetes Clinic
RECRUITING
Kawaguchi
Higashijujo Sakai Diabetes Internal Medicine Clinic
RECRUITING
Kita-ku
Tokuyama Clinic
RECRUITING
Mihama-ku,chiba City
Shinkenko clinic
RECRUITING
Naha
Oyama East Clinic
RECRUITING
Oyama
Shimokitazawa Tomo Clinic
RECRUITING
Setagaya-ku
Soka Sugiura Internal Medicine Clinic
RECRUITING
Sōka
Tsuchiura Beryl Clinic
RECRUITING
Tsuchiura
Tsuchiura Medical & Health Care Center
RECRUITING
Tsuchiura
Nagase Diabetes Clinic
RECRUITING
Ushiku
Yokohama Minoru Clinic
RECRUITING
Yokohama
Mexico
Centro de Investigacion Medica de Occidente, S.C.
NOT_YET_RECRUITING
Guadalajara
Instituto Jalisciense de Investigacion en Diabetes y Obesidad
NOT_YET_RECRUITING
Guadalajara
Unidad de Investigación Clínica y Atención Médica HEPA S.C.
NOT_YET_RECRUITING
Guadalajara
Medical Care and Research SA de CV
NOT_YET_RECRUITING
Mérida
Cardiolink Clin Trials
NOT_YET_RECRUITING
Monterrey
Poland
Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna
RECRUITING
Bialystok
Centrum Medyczne NEUROMED
RECRUITING
Bydgoszcz
Ambulatorium Sp. z o.o.
RECRUITING
Elblag
Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
RECRUITING
Krakow
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
RECRUITING
Lodz
Ekamed
RECRUITING
Lublin
NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki
RECRUITING
Ruda Śląska
Samodzielny Publiczny Szpital Kliniczny nr 1 SUM
RECRUITING
Zabrze
Puerto Rico
Centro de Endocrinologia y Nutricion
RECRUITING
Caguas
Dorado Medical Complex
RECRUITING
Dorado
Republic of Korea
Korea University Ansan Hospital
RECRUITING
Ansan-si
Hanyang University Guri Hospital
RECRUITING
Guri-si
Chosun University Hospital
RECRUITING
Gwangju
Seoul National University Bundang Hospital
RECRUITING
Seongnam
Severance Hospital, Yonsei University Health System
RECRUITING
Seoul
Slovakia
Diacrin s.r.o.
RECRUITING
Bratislava
MediVet s.r.o.
RECRUITING
Malacky
B-Medical, s.r.o.
RECRUITING
Námestovo
FUNKYSTUFF s.r.o.
RECRUITING
Nové Zámky
DIA-MED CENTRUM s.r.o.
RECRUITING
Púchov
MEDI-DIA s.r.o.
RECRUITING
Sabinov
Spain
Hospital Universitario de La Ribera
ACTIVE_NOT_RECRUITING
Alzira
Hospital Clínic de Barcelona
ACTIVE_NOT_RECRUITING
Barcelona
Hospital Universitari Vall d'Hebron
ACTIVE_NOT_RECRUITING
Barcelona
Complejo Hospitalario Ruber Juan Bravo
ACTIVE_NOT_RECRUITING
Madrid
H.R.U Málaga - Hospital Civil
ACTIVE_NOT_RECRUITING
Málaga
Hospital Universitario Virgen de la Victoria
ACTIVE_NOT_RECRUITING
Málaga
Centro Médico Compostela
ACTIVE_NOT_RECRUITING
Santiago De Compostela
Hospital Universitario Virgen Del Rocio
ACTIVE_NOT_RECRUITING
Seville
Vithas Hospital Sevilla
ACTIVE_NOT_RECRUITING
Seville
Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING
Kaohsiung City
Chang Gung Memorial Hospital at Kaohsiung
RECRUITING
Kaohsiung Niao Sung Dist
National Taiwan University Hospital
RECRUITING
Taipei
Taipei Veterans General Hospital
RECRUITING
Taipei
Chang Gung Medical Foundation-Linkou Branch
RECRUITING
Taoyuan
Contact Information
Primary
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
LillyTrials@Lilly.com
317-615-4559
Backup
Physicians interested in becoming principal investigators please contact
clinical_inquiry_hub@lilly.com
Time Frame
Start Date: 2025-12-15
Estimated Completion Date: 2028-02
Participants
Target number of participants: 1035
Treatments
Experimental: Eloralintide Dose 1
Participants will receive eloralintide subcutaneously (SC)
Experimental: Eloralintide Dose 2
Participants will receive eloralintide SC
Experimental: Eloralintide Dose 3
Participants will receive eloralintide SC
Experimental: Eloralintide Dose 4
Participants will receive eloralintide SC
Placebo_comparator: Placebo
Participants will receive placebo SC
Related Therapeutic Areas
Sponsors
Leads: Eli Lilly and Company