Type A insulin resistance syndrome is a rare disorder characterized by severe insulin resistance, a condition in which the body's tissues and organs do not respond properly to the hormone insulin. Insulin normally helps regulate blood sugar levels by controlling how much sugar (in the form of glucose) is passed from the bloodstream into cells to be used as energy. In people with type A insulin resistance syndrome, insulin resistance impairs blood sugar regulation and ultimately leads to a condition called diabetes mellitus, in which blood sugar levels can become dangerously high.
Type A insulin resistance syndrome results from mutations in the INSR gene. This gene provides instructions for making a protein called an insulin receptor, which is found in many types of cells. Insulin receptors are embedded in the outer membrane surrounding the cell, where they attach (bind) to insulin circulating in the bloodstream. This binding triggers signaling pathways that influence many cell functions.
Type A insulin resistance syndrome is estimated to affect about 1 in 100,000 people worldwide. Because females have more health problems associated with the condition, it is diagnosed more often in females than in males.
Type A insulin resistance syndrome can have either an autosomal dominant or, less commonly, an autosomal recessive pattern of inheritance.
Ravi Savarirayan is in Parkville, Australia. Savarirayan is rated as an Elite expert by MediFind in the treatment of Type A Insulin Resistance Syndrome. He is also highly rated in 35 other conditions, according to our data. His top areas of expertise are Achondroplasia, Type A Insulin Resistance Syndrome, Acanthosis Nigricans, and Chondrodystrophy.
Masaki Matsushita is in Nagoya, Japan. Matsushita is rated as an Elite expert by MediFind in the treatment of Type A Insulin Resistance Syndrome. He is also highly rated in 14 other conditions, according to our data. His top areas of expertise are Acanthosis Nigricans, Type A Insulin Resistance Syndrome, Achondroplasia, and Hypochondroplasia.
Hiroshi Kitoh is in Nagoya, Japan. Kitoh is rated as an Elite expert by MediFind in the treatment of Type A Insulin Resistance Syndrome. He is also highly rated in 23 other conditions, according to our data. His top areas of expertise are Hypochondroplasia, Type A Insulin Resistance Syndrome, Acanthosis Nigricans, and Achondroplasia.
Published Date:updated Last, December
Published By: National Institutes of Health