Type A Insulin Resistance SyndromeSymptoms, Doctors, Treatments, Advances & More
Learn About Type A Insulin Resistance Syndrome
Type A insulin resistance syndrome is a rare disorder characterized by severe insulin resistance, a condition in which the body's tissues and organs do not respond properly to the hormone insulin. Insulin normally helps regulate blood sugar levels by controlling how much sugar (in the form of glucose) is passed from the bloodstream into cells to be used as energy. In people with type A insulin resistance syndrome, insulin resistance impairs blood glucose regulation and ultimately leads to a condition called diabetes mellitus, in which blood glucose levels can become dangerously high.
Type A insulin resistance syndrome results from mutations in the INSR gene. This gene provides instructions for making a protein called an insulin receptor, which is found in many types of cells. Insulin receptors are embedded in the outer membrane surrounding the cell, where they attach (bind) to insulin circulating in the bloodstream. This binding triggers signaling pathways that influence many cell functions.
Type A insulin resistance syndrome is estimated to affect about 1 in 100,000 people worldwide. Because females have more health problems associated with the condition, it is diagnosed more often in females than in males.
Type A insulin resistance syndrome can have either an autosomal dominant or, less commonly, an autosomal recessive pattern of inheritance.
St. Louis Children's Hospital
Stephen Stone is a Pediatric Endocrinologist practicing medicine in Saint Louis, Missouri. Dr. Stone is rated as an Elite provider by MediFind in the treatment of Type A Insulin Resistance Syndrome. He is also highly rated in 3 other conditions, according to our data. His clinical expertise encompasses Type A Insulin Resistance Syndrome, Acanthosis Nigricans, Diabetes Insipidus (DI), and Type 1 Diabetes (T1D).
St. Christopher's Pediatric Associates Endocrinology - E. Erie Avenue
Rita Kubicky is a Pediatric Endocrinologist practicing medicine in Philadelphia, Pennsylvania. Dr. Kubicky is rated as an Advanced provider by MediFind in the treatment of Type A Insulin Resistance Syndrome. She is also highly rated in 20 other conditions, according to our data. Her clinical expertise encompasses Acanthosis Nigricans, Type A Insulin Resistance Syndrome, Albright's Hereditary Osteodystrophy, and Pseudohypoparathyroidism. Dr. Kubicky is board certified in American Board Of Pediatrics.
Shen Qu practices practicing medicine in Putuo, China. Mr. Qu is rated as an Elite expert by MediFind in the treatment of Type A Insulin Resistance Syndrome. He is also highly rated in 20 other conditions, according to our data. His clinical expertise encompasses Type A Insulin Resistance Syndrome, Acanthosis Nigricans, Melasma, Sleeve Gastrectomy, and Gastrectomy.
Objectives: To correlate moderate to severe acanthosis nigricans with diabetes complication Methodology: T2DM patient will be recruited from endocrine OPD 1\. Clinical History and Examination: 1. General Physical Examination: Height, weight, waist circumference, hip circumference, BMI, Blood Pressure, Hand grip. Acanthosis Nigricans. 2. Complications Assessment: Patient will be analysed for: Micro Vascular (a...
Published Date: December 01, 2014
Published By: National Institutes of Health