What is the definition of Type B Insulin Resistance Syndrome?
Insulin resistance type B syndrome is a very rare form of diabetes that occur in individuals with an autoimmune disorder, usually lupus erythematosus. In insulin resistance type B syndrome, abnormal antibodies block insulin, causing a build-up of glucose (sugar) in the blood. Insulin resistance type B syndrome mainly affects middle-aged females.
What are the symptoms for Type B Insulin Resistance Syndrome?
Symptoms of insulin resistance type B syndrome may include sudden onset of diabetes that is difficult to control; weight loss; increased appetite; darkening of the skin on the face, underarms, and around the groin (acanthosis nigricans); high testosterone levels in women; irregular or absent menstruation; abnormal hair growth on the face and back in women (hirsutism); and low blood sugar.
What are the current treatments for Type B Insulin Resistance Syndrome?
Treatment for insulin resistance type B syndrome involves very high doses of insulin and metformin to control high blood sugar and immunosuppressive drugs, such as rituximab, to treat the underlying autoimmune disorder.