A Phase 2b Randomized, Double-blind, Active-and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Induction and Maintenance Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis
Who is this study for? Patients with Ulcerative Colitis
Status: Active_not_recruiting
Location: See all (401) locations...
Intervention Type: Biological, Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The purpose of this study is to evaluate the efficacy and safety of JNJ-78934804 as compared to guselkumab and golimumab in participants with moderately to severely active ulcerative colitis who have had an inadequate initial response, loss of response, or intolerance to one or more approved advanced therapy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• Confirmed diagnosis of ulcerative colitis (UC) for at least 3 months prior to baseline
• Moderately to severely active UC as assessed by the modified Mayo score
• Demonstrated inadequate response, loss of response, or intolerance to at least one biologic or novel oral with biologic-like activity
• If female and of childbearing potential, must meet the contraception and reproduction requirements
Locations
United States
California
Valley Gastroenterology Medical Group
Arcadia
Southern California Research Center
Coronado
Om Research LLC
Lancaster
Cedars Sinai Medical Center
Los Angeles
University of California San Francisco
San Francisco
Colorado
University of Colorado
Aurora
Peak Gastroenterology Associates
Colorado Springs
Connecticut
Medical Research Center of Connecticut
Hamden
Yale University
New Haven
Washington, D.c.
MedStar Georgetown University Hospital
Washington D.c.
Florida
Pioneer Research Solutions Inc.
Coconut Creek
Digestive and Liver Disease Institute
Kissimmee
Osceola Regional Hospital
Kissimmee
Florida Research Center Inc.
Lakewood Rch
University of Miami
Miami
Gastroenterology Group Of Naples
Naples
Omega Research Consultants
Orlando
Synergy Clinical Research
St. Petersburg
GCP Clinical Research
Tampa
Georgia
Atlanta Gastroenterology Associates
Atlanta
Gastroenterolgy Associates of Central GA
Macon
Atlanta Gastroenterology Associates
Marietta
Gastrointestinal Specialists of Georgia
Marietta
Gastroenterology Consultants
Roswell
Idaho
Grand Teton Gastroenterology
Idaho Falls
Indiana
IU Health University Hospital
Indianapolis
Gastroenterology of Southern Indiana
New Albany
Kentucky
Tri-State Gastroenterology Assoc
Crestview Hills
University of Kentucky Chandler Medical Center
Lexington
Jewish Hospital
Louisville
Massachusetts
Beth Israel Deaconess Medical Center
Boston
Brigham And Women's Hospital
Chestnut Hill
Maryland
Chevy Chase Clinical Research
Chevy Chase
Michigan
Huron Gastroenterology Associates Center for Digestive Care
Ypsilanti
Missouri
Washington University
St Louis
North Carolina
University North Carolina at Chapel Hill
Chapel Hill
Onsite Clinical Solutions
Charlotte
Tryon Medical Group
Charlotte
Care Access Research, Kinston
Kinston
New Hampshire
Dartmouth Hitchcock
Lebanon
Nevada
Care Access Las Vegas
Las Vegas
Las Vegas Medical Research
Las Vegas
New York
Lenox Hill Hospital
New York
Weill Cornell Medical College
New York
Mohawk Valley Endoscopy Center
Utica
Ohio
Great Lakes Gastroenterology Research, LLC
Mentor
Pennsylvania
Frontier Clinical Research
Uniontown
South Carolina
Medical University of South Carolina
Charleston
Digestive Disease Associates
Rock Hill
Tennessee
Gastro One
Germantown
Etsu Quillen College Of Medicine
Johnson City
Vanderbilt University Medical Center
Nashville
Texas
UT Southwestern Medical Center
Dallas
GI Specialists of Houston
Houston
Gastroenterology Clinic Of San Antonio P A
San Antonio
Texas Digestive Disease Consultants
Southlake
Tyler Research Institute, LLC
Tyler
Virginia
Medical College Of Virginia Hospital
Richmond
Washington
Washington Gastroenterology, PLLC
Bellevue
Swedish Medical Center
Seattle
Virginia Mason Medical Center
Seattle
Digestive Health Specialists
Tacoma
Wisconsin
Medical College Of Wisconsin
Milwaukee
Other Locations
Argentina
CIPREC
Buenos Aires
Hospital Britanico de Buenos Aires
Buenos Aires
Hospital de Gastroenterología Dr. Carlos Bonorino Udaondo
Ciudad Autonoma Buenos Aires
Sanatorio Duarte Quiroz
Córdoba
Centro de Investigaciones Medicas Mar Del Plata
Mar Del Plata
Hospital Provincial del Centenario
Rosario
Australia
Box Hill Hospital
Box Hill
Royal Prince Alfred Hospital
Camperdown
Monash Health, Monash Medical Centre
Clayton
Concord Hospital
Concord
Western Health
Footscray
Coastal Digestive Health
Maroochydore
Fiona Stanley Hospital
Murdoch
Royal Adelaide Hospital
North Terrace
Royal Melbourne Hospital
Parkville
The Alfred Hospital
Prahran
Mater Hospital Brisbane
South Brisbane
Austria
Universitaetsklinikum Salzburg Landeskrankenhaus
Salzburg
Krankenhaus der Barmherzigen Brüder
Vienna
Medizinische Universitaet Wien
Vienna
Klinikum Wels Grieskirchen
Wels
Belgium
Imelda Ziekenhuis
Bonheiden
Algemeen Ziekenhuis Sint-Jan
Bruges
Cliniques Universitaires Saint Luc
Brussels
AZ Maria Middelares
Ghent
UZ Gent
Ghent
UZ Leuven
Leuven
CHC MontLegia
Liège
CHU de Liege
Liège
Vitaz
Sint-niklaas
Brazil
Universidade Estadual Paulista 'Julio De Mesquita Filho'
Botucatu
Chronos Clinica Medica LTDA Chronos Pesquisa Clinica
Brasília
L2IP Instituto de Pesquisas Clinicas
Brasília
Fundacao Universidade de Caxias do Sul
Caxias Do Sul
Centro Digestivo de Curitiba - Instituto de Pesquisa Clínica
Curitiba
Associacao Hospitalar Moinhos de Vento
Porto Alegre
Hospital das Clinicas de Porto Alegre
Porto Alegre
Hospital De Clinicas De Porto Alegre
Porto Alegre
Universidade Federal do Rio de Janeiro - Faculdade de Medicina
Rio De Janeiro
SER - Servicos Especializados em Reumatologia da Bahia
Salvador
Pesquisare Saude
Santo André
Irmandade da Santa Casa da Misericórdia de Santos
Santos
BR Trials
São Paulo
Hospital Nove de Julho
São Paulo
Instituto D Or de Pesquisa e Ensino IDOR
São Paulo
Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE
São Paulo
Bulgaria
Medical Centre Hipocrat
Haskovo
Diagnostic Consulting Center I Sliven
Sliven
UMHAT 'Tsaritsa Yoanna'
Sofia
University Hospital Alexandrovska - Clinic of Nephrology
Sofia-grad
Medical Center -Medika Plus
Veliko Tarnovo
Multriprofile Hospital for Active Treatment Hristo Botev
Vratsa
Canada
Viable Clinical Research
Bridgewater
Foothills Hospital
Calgary
Viable Clinical Research
Dartmouth
Covenant Health/Grey Nuns hospital
Edmonton
Gastroenterology and Internal Medicine Research Institute (GIRI)
Edmonton
Nova Scotia Health Authority
Halifax
London Health Sciences Centre - University Campus
London
CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont
Montreal
McGill University - Health Centre - Montreal General Hospital
Montreal
CMIIM, Centre médical L'Enjeu
Mount Royal
Columbia Gastroenterology
New Westminster
Hopital Chicoutimi
Saguenay
St. Jerome Medical Research
Saint-jérôme
Toronto Immune and Digestive Health Institute Inc
Toronto
GIRI Gastrointestinal Research Institute
Vancouver
The Gordon & Leslie Diamond Health Care Center
Vancouver
The Medical Arts Health Research Group
Vancouver
PerCuro Clinical Research Ltd.
Victoria
Health Sciences Centre
Winnipeg
Chile
Hospital Clinico Regional Dr. Guillermo Grant Benavente
Concepción
Centro de Estudios Clínicos e Investigación Médica (CeCim)
Santiago
Clinica Dermacross S A
Santiago
Complejo Asistencial Hospital Dr. Sótero del Río
Santiago
China
China Japan Friendship Hospital
Chaoyang
West China Hospital Sichuan University
Chengdu
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou
Jinhua municipal central hospital
Jinhua
Zhongda Hospital Southeast University
Nanjing
Union Hospital Tongji Medical College of Huazhong University of Science and Technology
Wuhan
Croatia
Opca bolnica Bjelovar
Bjelovar
University Hospital Center Split
Split
University Hospital Dubrava
Zagreb
Denmark
Aalborg Hospital
Aalborg
Aarhus University Hospital
Aarhus
Bispebjerg Og Frederiksberg Hospital
Copenhagen
Herlev Hospital, University of Copenhagen
Herlev
Odense Universitetshospital
Odense
Estonia
East Tallinn Central Hospital
Tallinn
West Tallinn Central Hospital
Tallinn
Tartu University Hospital
Tartu
France
CHU Amiens - Hopital Sud
Amiens
Hopital Louis Mourier
Colombes
Centre Hospitalier Universitaire(CHU) - Hopital Henri Mondor
Créteil
CHU Grenoble
Grenoble
Centre Hospitalier Départemental VENDEE
La Roche-sur-yon
CHRU de Lille Hopital Claude Huriez
Lille
Hopital Nord Marseille
Marseille
Hopital Saint Eloi
Montpellier
Clinique Ambroise Pare
Neuilly-sur-seine
CHU de Nice Hopital de l Archet
Nice
CHU Nimes Hopital Caremeau
Nîmes
Hopital Haut-Leveque, CMC Magellan
Pessac
Hospices Civils de Lyon HCL
Pierre-bénite
CHU Saint Etienne
Saint-etienne
Hopital de Rangueil
Toulouse
CHRU Nancy Brabois
Vandœuvre-lès-nancy
Germany
Charite - Universitaetsmedizin Berlin (CCM)
Berlin
Charite Universitaetsmedizin Berlin - Campus Charite Mitte
Berlin
Krankenhaus Waldfriede Mitte
Berlin
Praxis Fur Gastroenteroligie
Berlin
University Hospital Dresden
Dresden
Universitaetsklinik Erlangen
Erlangen
JWG-University Hospital
Frankfurt
Agaplesion Frankfurter Diakonie Kliniken GmbH, Markus Krankenhaus
Frankfurt Am Main
Universitatsklinikum Freiburg
Freiburg Im Breisgau
Klinikum Fulda - Tumorklinik - Germany
Fulda
BSF Studiengesellschaft
Halle
Martin-Luther-Universitaet Halle-Wittenberg - Universitaetsk
Halle
Medizinische Hochschule Hannover
Hanover
Gastroenterology Outpatient Clinic Prof. Ehehalt/Dr. Hemstäd
Heidelberg
University Hospital Heidelberg
Heidelberg
Universitatsklinikum Jena
Jena
Praxisgemeinschaft Jerichow
Jerichow
Gastroenterologische Spezialpraxis - Berlin-Karlshorst
Karlshorst
Eugastro GmbH
Leipzig
Staedtisches Klinikum Lueneburg
Lüneburg
Universitaetsklinikum Mannheim
Mannheim
Gastroenterologische Gemeinschaftspraxis Minden
Minden
Klinikum der Universitaet Muenchen
Munich
MVZ Portal 10
Münster
Praxis fur Innere Medizin und Gastroenterologie
Münster
Medius Klinik Nurtingen
Nürtingen
Siloah St Trudpert Klinikum
Pforzheim
Zentrum für Gastroenterologie Saar MVZ GmbH
Saarbrücken
Universitaetsklinik Tuebingen
Tübingen
Universitatsklinikum Ulm
Ulm
Gemeinschaftspraxis Jakobeit
Wipperfürth
Universitatsklinikum Wurzburg
Würzburg
Greece
Alexandra General Hospital of Athens
Athens
Sotiria General State Hospital of Chest Diseases
Athens
Nikaia General Hospital
Piraeus
Hippokration Hospital
Thessaloniki
Hungary
Magyar Honvedseg Egeszsegugyi Kozpont
Budapest
Obudai Egeszsegugyi Centrum Kft
Budapest
Pannónia Magánorvosi Centrum Kft
Budapest
Semmelweis Egyetem
Budapest
Bugat Pal Korhaz
Gyöngyös
Szegedi Tud Egyetem Szent Gyorgyi Albert Klin Kozp
Szeged
Markusovszky Egyetemi Oktatokorhaz
Szombathely
India
M S Ramaiah Medical College and Hospital
Bangalore
Siksha O Anusandhan University - Institute of Medical Scienc
Bhubaneswar
Apex Hospitals Ltd
Jaipur
All India Institute of Medical Sciences
New Delhi
Fortis Hospital
New Delhi
G.B. Pant Hospital
New Delhi
Sir Ganga Ram Hospital
New Delhi
Yashoda Super Speciality Hospitals
Secunderabad
Surat Institute of Digestive Sciences Hospitals
Surat
Israel
Haemek Medical Center - Afula
Afula
Bnai Zion Medical Center
Haifa
Rambam Medical Center
Haifa
Hadassah Hebrew University Medical Center
Jerusalem
Shaare Zedek Medical Center
Jerusalem
Rabin Medical Center Beilinson Campus
Petah Tikva
Kaplan Medical Center
Rehovot
Tel Aviv Sourasky Medical Center
Tel Aviv
The Chaim Sheba Medical Center
Tel Litwinsky
Assaf Harofeh Medical Center
Tzrifin
Italy
Università degli Studi di Bari
Bari
A.O. Per L' Emergenza Cannizzaro - U.O. Chirurgia Generale
Catania
AOU Policlinico G.Martino
Messina
Ospedale San Raffaele HSR Istituto Scientifico Universitario San Raffaele
Milan
Azienda Ospedaliero Universitaria di Cagliari - Policlinico Duilio Casula di Monserrato
Monserrato
Azienda Ospedaliera San Gerardo
Monza
Ospedale Sacro Cuore Don Calabria
Negrar
Ospedale Villa Sofia-Cervello
Palermo
Policlinico Universitario Agostino Gemelli
Roma
Università Campus Biomedico di Roma
Roma
IRCCS Humanitas Rozzano-IBD Center Malattie Infiammatorie Croniche Intestinali
Rozzano
Casa Sollievo della Sofferenza
San Giovanni Rotondo
Japan
Asahikawa Medical University Hospital
Asahikawa
Tokyo Medical and Dental University Hospital
Bunkyō City
Fukuoka University Chikushi Hospital
Chikushino-shi
Kitakyushu Municipal Medical Center
Fukuoka-ken
Gifu Prefectural General Medical Center
Gifu
Tokai University Hachioji Hospital
Hachiōji
Hamamatsu University Hospital
Hamamatsu
Hirosaki University Hospital
Hirosaki
National Hospital Organization Hirosaki General Medical Center
Hirosaki
Tokai University Hospital
Isehara
Kagoshima IBD Gastroenterology Clinic
Kagoshima
Kagoshima University Hospital
Kagoshima
Ofuna Chuo Hospital
Kamakura
Matsushima Clinic
Kanagawa
Nara Medical University Hospital
Kashihara
Tsujinaka Hospital Kashiwanoha
Kashiwa
Kobe University Hospital
Kobe
Yamanashi Prefectural Central Hospital
Kofu
Kumamoto University Hospital
Kumamoto
Kurume University Hospital
Kurume
Kyoto University Hospital
Kyoto
University Hospital Kyoto Prefectural University of Medicine
Kyoto
Gunma University Hospital
Maebashi
Kitasato University Kitasato Institute Hospital
Minatoku
Kyorin University Hospital
Mitaka
Iwate Medical University Hospital
Morioka
Nagoya City University Hospital
Nagoya
Nagoya University Hospital
Nagoya
The Hospital of Hyogo College of Medicine
Nishinomiya
Ogaki Municipal Hospital
Ōgaki
Oita Red Cross Hospital
Ōita
Japan Community Health Care Organization Osaka Hospital
Osaka
Kinshukai Infusion Clinic
Osaka
National Hospital Organization Osaka National Hospital
Osaka
Osaka City University Hospital
Osaka
Toho University Sakura Medical Center
Sakura
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
Sapporo
Sapporo Higashi Tokushukai Hospital
Sapporo
Sapporo Tokushukai Hospital
Sapporo
Sapporo IBD Clinic
Sapporo Chuo-ku
Tokyo Metropolitan Bokutoh Hospital
Sumida Ku
National Hospital Organization Tokyo Medical Center
Tokyo
The Jikei University Hospital
Tokyo
Tokyo Medical University Hospital
Tokyo
Tokyo Saiseikai Central Hospital
Tokyo
Oji General Hospital
Tomakomai
Toyama Prefectural Central Hospital
Toyama
Toyota Kosei Hospital
Toyota
Mie University Hospital
Tsu
University of Tsukuba Hospital
Tsukuba
Wakayama Medical University Hospital
Wakayama
Yokohama City University Medical Center
Yokohama
Jordan
Istishari Hospital
Amman
Jordan University Hospital
Amman
Irbid Specialty Hospital
Irbid
King Abdullah University Hospital
Irbid
Netherlands
Academisch Medisch Centrum Universiteit van Amsterdam
Amsterdam
Albert Schweitzer Ziekenhuis
Dordrecht
Maastricht University Medical Centre
Maastricht
Erasmus Medisch Centrum
Rotterdam
UMC Utrecht
Utrecht
New Zealand
Christchurch Hospital
Christchurch
Dunedin Hospital
Dunedin
Hutt Hospital
Lower Hutt
Wellington Hospital
Wellington
Norway
Alesund sjukehus
Ålesund
Vestre Viken HF Baerum Sykehus
Gjettum
Sykehuset Innlandet HF Gjøvik
Gjøvik
Akershus Universitetssykehus
Lørenskog
Oslo University Hospital HF Ulleval sykehus
Oslo
Universitetssykehuset Nord-Norge HF
Tromsø
Poland
Szpital Uniwersytecki No2
Bydgoszcz
Centrum Medyczne Plejady
Krakow
Centrum Medyczne Promed
Krakow
AmiCare Centrum Medyczne
Lodz
ETG Lublin
Lublin
Gastromed Spotka Z Ograniczona Odpowiedzialnoscia Sp. K.
Lublin
Allmedica
Nowy Targ
Wojewodzki Szpital Specjalistyczny w Olsztynie
Olsztyn
Synexus Polska Sp z o o
Poznan
Twoja Przychodnia
Poznan
Centrum Medyczne Medyk
Rzeszów
Endoskopia Sp z o.o.
Sopot
Sonomed Sp. z o.o.
Szczecin
Twoja Przychodnia - Szczecinskie Centrum Medyczne
Szczecin
GASTROMED Sp. z o.o.
Torun
Bodyclinic Sp. z o.o. sp. k
Warsaw
Centralny Szpital Kliniczny Mswia
Warsaw
Centrum Zdrowia Matki Dziecka i Mlodziezy
Warsaw
NZOZ Vivamed
Warsaw
Reumatika-Centrum Reumatologii, NZOZ
Warsaw
Centrum Diagnostyczno - Lecznicze Barska sp. z o.o. Szpital Specjalistyczny Barska
Włocławek
Centrum Medyczne Oporow
Wroclaw
EuroMediCare Szpital Specjalistyczny z Przychodnia
Wroclaw
Melita Medical Sp. z o.o.
Wroclaw
Przychodnia Vistamed
Wroclaw
ETG Zamosc
Zamość
Portugal
Centro Hospitalar de Lisboa Norte Hospital Santa Maria
Lisbon
Uls Loures Odivelas - Hosp. Loures
Loures
Hospital de Portimao-Centro Hospitalar do Barlavento Algarvio
Portimão
Centro Hospitalar de Entre o Douro e Vouga, E.P.E
Santa Maria Da Feira
Uls Gaia Espinho
Vila Nova De Gaia
Republic of Korea
Inje University Haeundae Paik Hospital
Busan
Kosin University Gospel Hospital
Busan
Yeungnam University Hospital
Daegu
Chosun university hospital
Gwangju
The Catholic university of Korea, St. Vincent's Hospital
Gyeonggi-do
Hallym University Dongtan Sacred Heart Hospital
Hwaseong-si
Asan Medical Center
Seoul
Gangnam Severance Hospital, Yonsei University Health System
Seoul
Kangbuk Samsung Hospital
Seoul
Kyung Hee University Hospital
Seoul
Severance Hospital Yonsei University Health System
Seoul
The Catholic University of Korea Seoul St.Mary's Hospital
Seoul
The Catholic University of Korea Seoul St.Mary's Hospital
Seoul
Ajou University Hospital
Suwon
Yonsei University Wonju Severance Christian Hospital
Wŏnju
Slovakia
FNsP F.D.R. Banska Bystrica
Banská Bystrica
Cliniq s.r.o.
Bratislava
GASTRO I. s.r.o.
Prešov
Gastroenterology Department ENDOMED, s.r.o.
Vranov Nad Topľou
Slovenia
Splosna bolnisnica Celje
Celje
Univerzitetni klinicni center Ljubljana
Ljubljana
South Africa
Worthwhile Clinical Trials Lakeview Hospital
Benoni
Groote Schur Hospital
Cape Town
Mediclinic Panorama
Cape Town
Practice Dr Naeem Moosa
Johannesburg
Emmed Research
Pretoria
Spain
Hosp Clinic de Barcelona
Barcelona
Hosp. Univ. La Paz
Madrid
Hosp. de Navarra
Pamplona
Hosp. Montecelo
Pontevedra
Corporacio Sanitari Parc Tauli
Sabadell
Hosp. Univ. Marques de Valdecilla
Santander
Hosp. Univ. de Torrejon
Torrejón De Ardoz
Hosp. Alvaro Cunqueiro
Vigo
Sweden
Karolinska Universitetssjukhuset Solna
Solna
Ersta sjukhus
Stockholm
Switzerland
Universitatsspital Basel
Basel
Gastroenterologische Praxis Balsiger und Seibold
Bern
Inselspital Universitatsspital Bern
Bern
Kantonsspital St Gallen
Sankt Gallen
UniversitaetsSpital Zuerich
Zurich
Taiwan
Changhua Christian Hospital
Changhua
China Medical University Hospital
Taichung
Taichung Veterans General Hospital
Taichung
National Cheng Kung University Hospital
Tainan
National Taiwan University Hospital, Division of Infectious Diseases
Taipei
Chang-Gung Memorial Hospital, LinKou Branch
Taoyuan District
United Kingdom
Royal Victoria Hospital
Belfast
Addenbrooke's Hospital
Cambridge
Queen Elizabeth University Hospital
Glasgow
Velocity Clinical Research
High Wycombe
Chelsea And Westminster Hospital
London
St Georges University Hospital NHS Foundation Trust
London
John Radcliffe Hospital
Oxford
Time Frame
Start Date: 2022-09-19
Completion Date: 2029-03-27
Participants
Target number of participants: 577
Treatments
Placebo_comparator: Group 1: Placebo
Participants will receive placebo subcutaneously (SC). All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension.
Experimental: Group 2: Guselkumab
Participants will receive guselkumab dose regimen 1 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension.
Experimental: Group 3: Golimumab
Participants will receive golimumab dose regimen 1 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension.
Experimental: Group 4: JNJ-78934804 (High-dose)
Participants will receive JNJ-78934804 dose regimen 1 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension.
Experimental: Group 5: JNJ-78934804 (Mid-dose)
Participants will receive JNJ-78934804 dose regimen 2 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension.
Experimental: Group 6: JNJ-78934804 (Low-dose)
Participants will receive JNJ-78934804 dose regimen 3 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension.
Related Therapeutic Areas
Sponsors
Leads: Janssen Research & Development, LLC