Repurposing Atorvastatin in Patients With Ulcerative Colitis Treated With Mesalamine by Modulation of mTOR/NLRP3 Pathway.
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
Statins exert numerous pleiotropic effects including anti-inflammatory, antioxidant properties, endothelial function improvement, and immunomodulation independent of their basic lipid-lowering properties.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Age ≥ 18 years
• Both males and females will be included
• Negative pregnancy test and effective contraception.
Locations
Other Locations
Egypt
Faculty of Medicine, Mansoura University
RECRUITING
Al Mansurah
Contact Information
Primary
Mostafa Bahaa, PhD
mbahaa@horus.edu.eg
0201025538337
Time Frame
Start Date: 2023-02-01
Estimated Completion Date: 2027-09-20
Participants
Target number of participants: 44
Treatments
Other: Control Group
This group will take mesalamine 1 g three times daily
Active_comparator: Atorvastatin group
This group will take mesalamine 1 g three times daily plus atorvastatin 80 mg once daily.
Related Therapeutic Areas
Sponsors
Leads: Tanta University