Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Crohn's Disease (CD) and Ulcerative Colitis (UC), collectively known as inflammatory bowel disease (IBD), are two of the most significant chronic conditions of the gastrointestinal tract (GIT) and affects over 1.5 million individuals in the U.S. Recently, there has been an increased understanding of the importance of sleep and sleep disruption in IBD as a potentially modifiable risk factor. We, therefore, hypothesize that intervening with morning bright light therapy (BLT) in IBD patients with CM will decrease intestinal permeability and pro-inflammatory cytokines, positively impact intestinal microbiota, and improve quality of life (QoL).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Biopsy proven diagnosis of Crohn's or Ulcerative Colitis

• 18 years or older

• Fecal Calprotectin \> 50 or CRP above upper limit of normal or a PROMISE Fatigue ≥ 50

• Has been on a stable dose of either a biologic, immunomodulator, or 5-ASA for at least 12 weeks

Locations
United States
Illinois
Rush University Medical Center
RECRUITING
Chicago
South Carolina
Medical University of South Carolina
RECRUITING
Charleston
Contact Information
Primary
Daynia Sanchez-Bass
daynia_sanchez-bass@rush.edu
(312) 563-4981
Time Frame
Start Date: 2022-09-22
Estimated Completion Date: 2026-05-31
Participants
Target number of participants: 30
Treatments
Experimental: Bright Light Therapy via ReTimer glasses, Then Placebo
Participants will wear their device for 60 minutes every morning for 28-days (4 weeks)
Experimental: No Bright Light Therapy via placebo glasses, Then Bright Light Therapy
Participants will wear their placebo device for 60 minutes every morning for 28-days (4 weeks)
Sponsors
Leads: Rush University Medical Center

This content was sourced from clinicaltrials.gov