Dietary Modification In Patients With Inflammatory Bowel Diseases And Its Impact In Gut Microbiome

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This research project aimed to develop a culturally appropriate Asian Inflammatory Bowel Disease Diet for the Malaysian population, based on the Crohn's disease exclusion diet (CDED). The study will be conducted in inflammatory bowel disease patients in University Malaya Medical Centre, which are ulcerative colitis and Crohn's disease patients. The objectives of this study are to assess the impact of diet in clinical outcome and gut microbiota changes in patients with inflammatory bowel disease (IBD). The study duration spans 24 weeks, during which comprehensive follow-ups will be conducted at 0, 6, 12, and 24 weeks, respectively. At each follow-up session, participants will be requested to provide stool and blood samples for meticulous assessment of clinical and biochemical responses.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: f
View:

• Confirmed diagnosis of Crohn's disease according to established clinical, endoscopic, and histological criteria.

• Mild to moderate diseases (150 to 220 points).

• Written informed consent obtained.

Locations
Other Locations
Malaysia
Universiti Malaya Medical Centre
RECRUITING
Kuala Lumpur
Contact Information
Primary
Ida Normiha Hilmi, MRCP PhD
ida@ummc.edu.my
0379492868
Backup
Nazihah Wafi, BMedSci
nazihahwafi@um.edu.my
0138058802
Time Frame
Start Date: 2025-03-01
Estimated Completion Date: 2026-02-10
Participants
Target number of participants: 74
Treatments
Active_comparator: General Healthy Diet Group
Participants in this group will follow the quarter-quarter-half plate diet based on the Malaysian Healthy Plate guideline.
Experimental: Crohn's Disease Exclusion Diet (CDED) Group
Participants in this group will follow the Crohn's Disease Exclusion Diet (CDED), which consists of three phases with specific dietary restrictions.
Sponsors
Leads: University of Malaya

This content was sourced from clinicaltrials.gov

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