Effect of Meal Timing and Dietary Changes on Metabolic and Behavioral Factors Involved in the Food Insecurity-Obesity Paradox

Status: Recruiting
Location: See location...
Intervention Type: Other, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study aims to explore how food insecurity, a lack of consistent access to enough food, may lead to changes in the body that make it harder to lose weight. The investigators are testing whether providing women experiencing food insecurity with a stable, healthy, and personalized meal plan can improve their metabolism and reduce their motivation to eat unhealthy foods. The hypothesis is that addressing food insecurity with a predictable diet can lower a person's respiratory quotient (a measure of how the body uses energy), promote fat burning, and improve overall health. This research will improve the understanding for how food insecurity contributes to obesity and may lead to better solutions for managing weight in individuals facing these challenges.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: f
View:

• Woman between the ages of 18-45.

• Premenopausal.

• Obese (BMI ≥ 30).

• Diagnosed with prediabetes (HbA1c: 5.7%-6.4%).

• Experiencing food insecurity (score of 2-6 on the six-item food insecurity questionnaire).

• Income below 300% of the household federal poverty threshold.

• Lives alone.

Locations
United States
New York
Farber Hall G56
RECRUITING
Buffalo
Contact Information
Primary
Nicholas V Neuwald, PhD Nutritional Sciences
nneuwald@buffalo.edu
5613548720
Backup
Leonard H. Epstein, PhD Experimental Psychology
lhenet@buffalo.edu
7169843075
Time Frame
Start Date: 2025-07-16
Estimated Completion Date: 2026-02-15
Participants
Target number of participants: 12
Treatments
No_intervention: Control phase
During this phase, participants are told to maintain typical behaviors and not change any normal patterns of activity/eating.
Experimental: Treatment phase
There are two components to the treatment:~Food provisioning: The food provisioning component will consist of bi-weekly home deliveries of three meals a day. The number of calories in the provided meals for each day will be personalized based on each participant's resting metabolic rate. Caloric targets for each participant will be 20% of TDEE as this translates to \~1-2 pounds of weight loss per week. Diets composition will also be tailored to help improve TEF and RQ.~Behavioral Skills Training: This will be based on an evidence-based behavioral weight-loss program developed in our lab. This treatment has shown clinically significant weight loss with positive effects sustained over 10-years. The specific includes lessons on self-monitoring, developing alternatives to foods, meal-planning, goal setting, episodic future thinking, physical activity, and self-reinforcement.
Related Therapeutic Areas
Sponsors
Leads: State University of New York at Buffalo
Collaborators: National Center for Advancing Translational Sciences (NCATS)

This content was sourced from clinicaltrials.gov