Synergistic Effects of Vitamin D and Calcium Supplementation on Hyperglycemia and Dyslipidemia in Patients With Gestational Diabetes

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Gestational diabetes mellitus (GDM) is becoming more common globally as a metabolic disease that occurs during pregnancy and influences the mother and the fetus. It has been linked to preeclampsia, C-section, and a higher lifetime risk of developing type 2 diabetes both for mother and the child. Another complication of GDM is dyslipidemia that also accentuates cardiovascular risks, so the care of lipid profiles is essential for the best pregnancy outcomes. The previous literature review indicates that micronutrients including vitamin D and calcium have a bearing on glucose and lipid profiles. Various studies have established that vitamin D improves the insulin response and lipid profile whereas calcium is vital in insulin and glucose homeostasis. Furthermore, it is revealed that calcium induces vitamin D so that it could undergo its full metabolic effect. Hence, the addition of vitamin D and calcium together may enhance glycemic management and lipid profiles of GDM patients. The aim of the present work is to compare the impact of vitamin D and calcium supplementation on lipid profiles and hyperglycemia in GDM patients. It will measure the major metabolic indices fasting plasma glucose, glycated hemoglobin (HbA1c) and lipid profile (LDL, HDL triglycerides) and review the effect of this on pregnancy outcomes. These outcomes will be assessed by a randomized-controlled trial.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 40
Healthy Volunteers: f
View:

• Pregnant women aged 18-40 years.

• Gestational age between 24-28 weeks.

• Diagnosis of GDM based on OGTT results.

• Willingness of participants to provide written informed consent.

Locations
Other Locations
Pakistan
Riphah International University
RECRUITING
Lahore
Contact Information
Primary
IMRAN AMJAD, PhD
Imran.amjad@riphah.edu.pk
9233224390125
Backup
Muhammed Imran Hussain, PhD
imran.hussain@riphah.edu.pk
+923004478597
Time Frame
Start Date: 2025-01-28
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 60
Treatments
Other: Arm and Interventions
Experimental: Vitamin D3 and calcium This group will be receive vitamin D3 600 IU and 1.5-2 g of calcium. This treatment will be conducted for 6 week per day after meal.
Other: Arm and placebo
: This group will receive a placebo containing no active ingredients and it will conducted for 6 weeks per day.
Sponsors
Leads: Riphah International University

This content was sourced from clinicaltrials.gov