Visualizing Beta Cells in Patients With Remission of T2DM After Bariatric Surgery

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Radiation
Study Type: Observational
SUMMARY

In order to evaluate the difference in beta cell mass in patients with and without complete resolution of type 2 diabetes mellitus (T2DM) after Roux en Y gastric bypass (RYGB) investigators aim to compare quantitative PET imaging of the pancreas between these patient groups. These highly relevant data will provide investigators with more information on the possible role of beta cell mass in the mechanisms behind resolution of T2DM after bariatric surgery. This would be of great interest for the assessment of RYGB as an alternative therapy in patients with T2DM with a BMI \<35, who currently do not meet the international guidelines for bariatric surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

⁃ For responders:

• Obese T2D patient who had undergone RYGB at least 1 year earlier

• Signed informed consent

• Complete resolution of T2D after surgery

⁃ For non-responders:

• Obese T2D patient who had undergone RYGB at least 1 year earlier

• Signed informed consent

• No complete resolution of T2D after surgery

Locations
Other Locations
Netherlands
Rijnstate Hospital
RECRUITING
Arnhem
RadboudUMC
RECRUITING
Nijmegen
Contact Information
Primary
Marti Boss, Msc
marti.boss@radboudumc.nl
+31-24-36
Backup
Martin Gotthardt, Prof. Dr.
martin.gotthardt@radboudumc.nl
+31-24-36
Time Frame
Start Date: 2015-08
Estimated Completion Date: 2024-07
Participants
Target number of participants: 24
Treatments
Responders
Patients with resolved type 2 diabetes after bariatric surgery, will undergo 68Ga-exendin PET/CT
Non-responders
Patients with unresolved type 2 diabetes after bariatric surgery, will undergo 68Ga-exendin PET/CT
Related Therapeutic Areas
Sponsors
Leads: Radboud University Medical Center
Collaborators: Rijnstate Hospital

This content was sourced from clinicaltrials.gov