Investigation of Pharmacokinetics, Safety and Tolerability of Multiple Subcutaneous Doses of NNC0519-0130 in Male Chinese Participants With Overweight or Obesity

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1
SUMMARY

Novo Nordisk is developing a new study medicine NNC0519-0130 to improve the treatment options for people living with type 2 diabetes and excess body weight. In this study, the concentration of NNC0519-0130 in the blood will be measured and its safety will be evaluated. The participants will either get NNC0519-0130 or placebo (a dummy substance), which treatment the participants get is decided by chance. This study will test up to 7 different doses of NNC0519-0130 and will last for about 28 weeks.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Maximum Age: 55
Healthy Volunteers: f
View:

• Male Chinese participant.

• Body Mass Index (BMI) between 24.0 and 39.9 kilogram per square meter (kg/m\^2) (both inclusive) at screening. Overweight should be due to excess adipose tissue, as judged by the investigator.

• Considered eligible based on the medical history, physical examination, and the results of vital signs, electrocardiogram (ECG) and clinical laboratory tests performed during the screening visit, as judged by the investigator.

Locations
Other Locations
China
Peking University Third Hospital, Northern branch-Phase I
RECRUITING
Beijing
Contact Information
Primary
Novo Nordisk
clinicaltrials@novonordisk.com
(+1) 866-867-7178
Time Frame
Start Date: 2025-05-26
Estimated Completion Date: 2026-04-07
Participants
Target number of participants: 20
Treatments
Experimental: NNC0519-0130
Participants will receive once weekly subcutaneous (s.c.) administration of NNC0519-0130 in dose escalation manner.
Placebo_comparator: Placebo
Participants will receive once weekly subcutaneous administration of placebo matched to NNC0519-0130.
Related Therapeutic Areas
Sponsors
Leads: Novo Nordisk A/S

This content was sourced from clinicaltrials.gov