Type 2 Diabetes (T2D) Clinical Trials

Find Type 2 Diabetes (T2D) Clinical Trials Near You

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Once-Weekly RO7795068 Administered to Participants With Obesity or Overweight and Type 2 Diabetes

Status: Recruiting
Location: See all (28) locations...
Intervention Type: Combination product
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

The purpose of this study is to assess the efficacy and safety of RO7795068, a dual glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist (RA), at multiple doses compared with placebo for weight management in participants with obesity or overweight and Type 2 diabetes mellitus (T2DM).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Ability and willingness to self-administer the study drug (or receive an injection from a trained individual if visually impaired or with physical limitations)

• Diagnosis of type 2 diabetes mellitus (T2DM) according to WHO classification or other locally applicable standards with HbA1c ≥6.5% to ≤10% determined by laboratory test at screening, and on stable oral therapy for at least 3 months prior to screening (if applicable). T2DM may be treated with diet/exercise alone or any oral anti-hyperglycemic medication (as per local labeling) EXCEPT dipeptidyl peptidase 4 (DPP-4) inhibitors or GLP-1 RA-based therapy.

• Body mass index (BMI) ≥27.0 kg/m\^2

• History of ≥1 self-reported unsuccessful diet/exercise effort to lose body weight

Locations
United States
Alabama
Lakeview Clinical Research
RECRUITING
Guntersville
Arizona
Arizona Clinical Trials
RECRUITING
Tucson
California
Orange County Research Center
RECRUITING
Lake Forest
Ark Clinical Research
RECRUITING
Long Beach
Catalina Research Institute, LLC
RECRUITING
Montclair
Washington, D.c.
Emerson Clinical Research Institute
RECRUITING
Washington D.c.
Florida
Progressive Medical Research
RECRUITING
Port Orange
Louisiana
Elevate Clinical Research
RECRUITING
Lake Charles
Maryland
Centennial Medical Group
RECRUITING
Columbia
North Carolina
Centricity Research Morehead City Multispeciality
RECRUITING
Morehead City
Ohio
Remington Davis Inc
RECRUITING
Columbus
Oklahoma
Essential Medical Research
RECRUITING
Tulsa
Texas
Juno Research, LLC
RECRUITING
Houston
Washington
Era Health Research
RECRUITING
Redmond
Other Locations
Australia
Paratus Clinical Western Sydney
RECRUITING
Blacktown
Canada
LMC Clinical Research Inc
RECRUITING
Toronto
Dr TG Elliott Inc
RECRUITING
Vancouver
Japan
Hasegawa Medicine Clinic
RECRUITING
Hokkaido
Higashijujo Sakai Diabetes Internal Medicine Clinic
RECRUITING
Tokyo
Taiwan
Changhua Christian Hospital
RECRUITING
Changhua
Chia-Yi Christian Hospital
RECRUITING
Chiayi City
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING
Kaohsiung City
China Medical University Hospital
RECRUITING
Taichung
Chung Shan Medical University Hospital
RECRUITING
Taichung
National Cheng Kung University Hospital
RECRUITING
Tainan
National Taiwan University Hospital
RECRUITING
Taipei
Taipei Veterans General Hospital
RECRUITING
Taipei
Thailand
Division of Endocrinology and Metabolism;Internal Medicine
RECRUITING
Chiang Mai
Contact Information
Primary
Reference Study ID Number: WC45726 https://forpatients.roche.com/
global-roche-genentech-trials@gene.com
888-662-6728 (U.S. Only)
Time Frame
Start Date: 2026-03-23
Estimated Completion Date: 2028-08-07
Participants
Target number of participants: 1600
Treatments
Placebo_comparator: Arm 1: Placebo
Experimental: Arm 2: RO7795068 Dosing Regimen 1
Experimental: Arm 3: RO7795068 Dosing Regimen 2
Experimental: Arm 4: RO7795068 Dosing Regimen 3
Related Therapeutic Areas
Sponsors
Leads: Hoffmann-La Roche

This content was sourced from clinicaltrials.gov