Molecular Markes of Fibrosis of Single Types of Endometriosis and Their Use in Predicting Disease Severity

Status: Recruiting
Intervention Type: Other
Study Type: Observational
SUMMARY

The primary aim of the project is to analyse gene expression in individual types of ectopic endometrium (ovarian endometriosis, peritoneal endometriosis, deep infiltrating endometriosis) and compare it with gene expression in eutopic endometrium. The analysis focuses on the identification of genes with significantly increased expression in each type of ectopic endometrium and comparison of their expression with the degree of disease, ovarian reserve and clinical manifestations of the disease (pain, infertility).

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: f
View:

• women (18-45 years)

• signed informed consent with the study

• absence of hormonal treatment 3 months before the planned procedure

⁃ \- laparoscopically and histologically confirmed endometriosis dg.

• patients without endometriosis

• patients who are undergoing an elective laparoscopic or hysteroscopic procedure in our department for another benign indication

• patients with excluded malignant disease

Time Frame
Start Date: 2023-04-01
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 120
Treatments
A-OE
women with ovarian endometriosis (study group)
A-PE
women with peitoneal endometriosis (study group)
A-DE
women with deep infiltrating endometriosis (study group)
B
women without endometriosis
Related Therapeutic Areas
Sponsors
Leads: General University Hospital, Prague

This content was sourced from clinicaltrials.gov