A Program to Develop Computerised Visual Function Tests for Cross Sectional Routine Clinical Practice and Long Term Monitoring to Detect Adverse Change in Visual Function.

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Clinical vision measurements usually involve printed charts with an eye care professional interpreting patient responses to generate a score. Those scores determine the need for or outcome of treatment. Detecting change can be improved with strict procedures/scoring, lending itself to computerisation. This in turn allows integration with electronic medical records. Many eye tests could be computerised in this way. At Guys and St Thomas' NHS Foundation Trust, the investigators have developed and validated a computerised test of distance visual acuity, called COMPlog which is now in widespread use. The investigators now want to increase the range of tests available. There is also a need to longitudinally monitor for adverse change. Such monitoring must be developed to keep false positive and false negative change detection to a minimum. The aims of this two year linked program are to: Part A) validate an extended range of computerised vision measurement tests against their gold standard hard copy printed equivalents. Some of these tests are designed for use in children and all are meant to quantify both normal and impaired vision. Patients of all ages and visual function will therefore be recruited from St Thomas' Hospital. The specific tests we aim to validate are logMAR Letter Near Acuity, Word Near Acuity, Letter Contrast Sensitivity, Auckland Optotypes Picture Acuity, Low Contrast Letter Acuity, Stereoacuity and Vanishing Optotypes. Patients will undergo test-retest measurements with up to two of these. Part B) Iteratively develop an application for use in home monitoring of subjects at risk of treatable vision loss due to age related macular degeneration. All computerised tests in parts A and B will be performed on prototype software. Eye patients will be recruited as subjects. Patients recruited to part A will undergo tests on one day for up to an hour, subjects in part B will participate for between 1 hour and two months.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 3
Maximum Age: 99
Healthy Volunteers: t
View:

• Male and female patients attending hospital eye clinics, aged 3 - 99, inclusive.

• Patients able to understand the information sheet, and willing and able to give informed consent to participate.

• Patients with visual function ranging from normal to severely impaired.

• Willing and able to comply with the visual function testing protocol.

• Some validation studies require recruitment of disease specific groups (such as children with amblyopia or adults with age related macular degeneration).

⁃ For Part B of the project which aims to develop and pilot a home monitoring application, only adult (18-99 years) subjects complying with the above who also own a suitable browser device will be recruited.

Locations
Other Locations
United Kingdom
St Thomas' Hospital NHS Foundation Trust
RECRUITING
London
Contact Information
Primary
Abigail Orr, BSc
eyeresearch@gstt.nhs.uk
020 7188 4885
Time Frame
Start Date: 2024-04
Estimated Completion Date: 2025-01
Participants
Target number of participants: 550
Treatments
Near logMAR letter acuity
Comparison of measurements made with the trial computerised test to the trial gold standard printed test
Near logMAR word acuity
Comparison of measurements made with the trial computerised test to the trial gold standard printed test
Letter Contrast Sensitivity
Comparison of measurements made with the trial computerised test to the trial gold standard printed test
Vanishing Optotype Sloan letters
Comparison of measurements made with the trial computerised test to the trial gold standard printed test
Auckland Optotypes/Auckland Vanishing Optotypes
Comparison of measurements made with the trial computerised test to the trial gold standard printed test
Low contrast letter acuity
Comparison of measurements made with the trial computerised test to the trial gold standard printed test
Red Green Stereoacuity
Comparison of measurements made with the trial computerised test to the trial gold standard printed test
Sponsors
Leads: Guy's and St Thomas' NHS Foundation Trust
Collaborators: King's College London

This content was sourced from clinicaltrials.gov