Primary Aldosteronism: a Study of Diagnostic Approach and Treatment Outcome in Western Norway

Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY

In this study the investigators aim to identify and include consecutively patients with primary aldosteronism (PA) diagnosed in the Western and Mid-parts of Norway, to describe the characteristics of these patients, to explore the cardiac effects of PA before and after specific treatment, and to identify long-term outcomes after treatment. One subgroup of the PA patients perform echocardiography to assess left ventricular systolic myocardial function before and after treatment. One subgroup of PA patients perform cardiac MRI to assess myocardial mass, myocardial fibrosis and myocardial function in rest and during stress, before and after treatment. For the cardiac MRI substudy, the PA patients are compared with a group of healthy controls, also included in the study. From 2022 onwards, PA patients diagnosed or subtyped with adrenal vein sampling at Oslo University Hospital will additionally be included in the study, thereby providing a national registration of PA patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: t
View:

• Verified diagnosis or strong suspicion of primary aldosteronism

• Age 18-85

Locations
Other Locations
Norway
Haukeland University Hospital
RECRUITING
Bergen
Oslo University Hospital
NOT_YET_RECRUITING
Oslo
Contact Information
Primary
Marianne A Grytaas, MD PhD
marianne.grytaas@helse-bergen.no
+4741545435
Backup
Kristian Løvås, Prof., MD
kristian.lovas@helse-bergen.no
+4755977996
Time Frame
Start Date: 2013-06
Estimated Completion Date: 2030-12
Participants
Target number of participants: 300
Treatments
Primary aldosteronism patients for cardiac MRI
A subgroup of primary aldosteronism (PA) patients perform a cardiac MRI, including stress-testing with adenosine, and are compared to a sex- and age-matched group of healthy controls who perform the same MRI procedure
Healthy controls
Healthy controls that are age-and sex-matched to the subgroup of PA patients performing cardiac MRI, perform MRI including adenosine as stress-test.
Primary aldosteronism patients diagnosed from 2013 onwards
All PA patients diagnosed or subtyped at Haukeland University from 2013 onwards are asked for inclusion in the main observational PA-study.~From 2025 onwards, PA patients diagnosed or subtyped at Oslo University hospital will also be included.
Related Therapeutic Areas
Sponsors
Collaborators: University Hospital of North Norway, Helse Fonna, St. Olavs Hospital, Oslo University Hospital, Helse Stavanger HF, Alesund Hospital
Leads: Haukeland University Hospital

This content was sourced from clinicaltrials.gov