Neuropsychological Assessment of Children and Adolescents With Turner Syndrome

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Behavioral
Study Type: Observational
SUMMARY

Turner syndrome (TS) is a rare chromosomal disorder characterized by partial or complete loss of one of the X chromosomes that affects about one in every 2000 female babies born. These young patients described difficulties making friends, understanding others' emotions and intentions, and controlling their own emotions. Difficulties in these domains could led to social withdrawal, to reduced social skills and could have a significant impact on self esteem and mental health as well as on long-term academic and social functioning in affected individuals. The purpose of this project is to identify functional and dysfunctional cognitive and socio-cognitive abilities in these young patients which could account social difficulties described by some of them and their family. To this end, 35 girls with TS and 35 girls with isolated growth hormone deficiency and normal cerebral MRI will be recruited. Subjects will be 7 to 16 years and 11 months of age. Socio-cognitive and cognitive functions will be assessed with neuropsychological and experimental tasks. Questionnaires completed by patient, parents or teacher, will evaluate social and behavioral functioning.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 7
Maximum Age: 16
Healthy Volunteers: f
View:

⁃ Turner syndrome group :

• girls with diagnosed Turner syndrome.

⁃ Isolated GHD group :

• girls with diagnosed isolated growth hormone deficiency

⁃ All participants :

• age between 7 years to 16 years and 11 months.

• informed consent signed by the participant and her parents (or her legal representatives)

• being registered in the national social security system

Locations
Other Locations
France
CHU Angers
RECRUITING
Angers
CHU Nantes
RECRUITING
Nantes
CHU Rennes
RECRUITING
Rennes
Contact Information
Primary
Régis Coutant, MD PhD
ReCoutant@chu-angers.fr
33(02)41-35-56-55
Backup
Emmanuel Quemener, CRA
EmQuemener@chu-angers.fr
33(02)41-35-45-81
Time Frame
Start Date: 2019-09-05
Estimated Completion Date: 2025-12-05
Participants
Target number of participants: 70
Treatments
Turner Syndrome
* 35 girls with Turner syndrome (except patients with part of a Y chromosome in their karyotype and r(X) cases).~* age : 7 years -16 years and 11 months.~* Psychological evaluation of cognition, social cognition and affective cognition
isolated GHD
* 35 girls with isolated Growth Hormone Deficiency (GHD).~* age : 7 years -16 years and 11 months.~* Psychological evaluation of cognition, social cognition and affective cognition
Sponsors
Leads: University Hospital, Angers

This content was sourced from clinicaltrials.gov