Longitudinal Changes in Eye Shape in Young Adults Treated With Low-Dose Atropine and Soft Multifocal Contact Lenses

Status: Recruiting
Location: See location...
Intervention Type: Device, Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The goal of this clinical trial is to study changes in eye shape of nearsighted young adults using low-dose atropine eye drops or soft multifocal contact lenses. The main questions it aims to answer are: * do low-dose atropine and soft multifocal contact lenses affect the shape of the peripheral eye? * are changes in peripheral eye shape from these interventions influenced by changes in the focusing system of the eye? Participants will: * have multiple different types of photos taken * have their prescription for glasses/contacts checked * have their eye health checked, including the use of dilating eye drops * be randomly assigned to use eye drops every night or wear special contact lenses daily instead of their typical contacts * will complete five study visits over the course of 12 months Researchers will compare young adults using low-dose atropine to those wearing soft multifocal contact lenses and to those using no intervention to see if using these interventions affects retinal shape.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 30
Healthy Volunteers: t
View:

• best corrected visual acuity of 20/25 or better in each eye

• nearsighted

• current contact lens wearer

• normal binocular vision (to be determined by an examiner at the first study visit)

Locations
United States
Ohio
The Ohio State University
RECRUITING
Columbus
Contact Information
Primary
Marielle G Reidy, OD, MS
reidy.39@osu.edu
614-688-0028
Backup
Donald O Mutti, OD, PhD
mutti.2@osu.edu
614-247-7057
Time Frame
Start Date: 2024-08-01
Estimated Completion Date: 2026-07-31
Participants
Target number of participants: 75
Treatments
No_intervention: Observation
Participants randomized to the observation arm will receive no intervention.
Experimental: Low-dose atropine
Participants randomized to low-dose atropine will instill one drop of 0.05% atropine in each eye at bedtime for 12 months.
Experimental: Soft multifocal contact lenses
Participants randomized to soft multifocal contact lenses will wear MiSight 1-day disposable contact lenses for 5-7 days per week for 12 months.
Related Therapeutic Areas
Sponsors
Leads: Ohio State University

This content was sourced from clinicaltrials.gov