Genetic Variants and Their Association With Myopia Risk, Progression, and Optimal Interventions in Children
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Genetic
Study Type: Observational
SUMMARY
This study aims to identify genetic factors linked to myopia, including those that influence a person's risk of developing it and how quickly it progresses (like changes in eye length). It will also examine how different treatments-such as low-dose atropine drops, orthokeratology lenses, specialized glasses, and increased outdoor time-interact with these genes. Finally, the research will develop a genetic risk score to help tailor personalized myopia prevention and treatment plans.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 6
Maximum Age: 18
Healthy Volunteers: t
View:
• Age 6-18 years.
• Any Spherical equivalent refraction (SER)
• Parental consent for genetic testing.
Locations
Other Locations
China
Beijing New Vision Eye Hospital
RECRUITING
Beijing
Beijing Visionly Plus Eye Hospital
RECRUITING
Beijing
Contact Information
Primary
Lin Yang, M.D.
roc001cn@gmail.com
+86-17898805125
Time Frame
Start Date: 2025-07-01
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 1000
Treatments
Genetic and myopia onset
Identify genetic variants (GWAS/WES) associated with:~* Myopia onset risk (high-risk SNPs ).~* Myopia progression rate (e.g., axial elongation/year).
Genetic and myopia intervention
Evaluate gene-intervention interactions for:~* Low-dose atropine (0.01%, 0.05%).~* Orthokeratology.~* Defocus-incorporated spectacles.~* Outdoor/sunlight exposure (≥2 hours/day).
Related Therapeutic Areas
Sponsors
Collaborators: Beijing New Vision Eye Hospital, High Myopia Control Alliance (HIMALAYA)
Leads: Beijing Visionly Plus Eye Hospital