Targeting the Motor Cortex in Parkinson's Disease by Gamma-transcranial Alternating Current Stimulation: Pathophysiological and Therapeutic Implications

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Cortical-basal ganglia gamma oscillations are pathologically reduced in Parkinson's disease (PD) and the plasticity of the primary motor cortex (M1) is impaired. Enhancing gamma oscillations through transcranial alternating current stimulation (tACS), a non-invasive neurophysiological tool that modulates cortical rhythms, can restore this alteration. However, whether tACS-related normalization of M1 plasticity results in positive clinical effects is unknown. Motor learning is also impaired in PD and gamma oscillations play a relevant role in different forms of learning in humans. Nevertheless, whether motor learning abnormalities relate to reduced gamma oscillations in PD is another unclear issue. It can be hypothesized that gamma oscillations impairment in M1 contributes to altered motor control, plasticity and learning in PD. Accordingly, in this project, the authors intend to test whether gamma-tACS on M1 in PD patients ameliorates motor performance and learning, as objectively assessed with kinematic techniques.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• PD diagnosis

Locations
Other Locations
Italy
IRCCS Neuromed
RECRUITING
Pozzilli
Contact Information
Primary
Giulia Paparella
giulia.paparella@uniroma1.it
3384780752
Time Frame
Start Date: 2023-04-29
Estimated Completion Date: 2026-04-29
Participants
Target number of participants: 84
Treatments
Experimental: gamma transcranial alternating current stimulation
Sham_comparator: sham transcranial alternating current stimulation
Related Therapeutic Areas
Sponsors
Leads: Neuromed IRCCS
Collaborators: I.R.C.C.S. Fondazione Santa Lucia, Fondazione Policlinico Universitario Campus Bio-Medico

This content was sourced from clinicaltrials.gov