Closed-loop Phase-adaptive Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Activity in the Cerebello-thalamo-cortical Network to Reduce Parkinson's Disease Tremor

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by different motor symptoms, including tremor, which is particularly difficult to manage. Common treatments, such as dopaminergic therapy, can have limitations in efficacy. Recent advancements in non-invasive brain stimulation, specifically phase-adaptive transcranial alternating current stimulation (tACS), offer a promising approach to reduce PD tremor. In the current project, a newly developed closed-loop system delivers precisely synchronized cerebellar tACS by aligning stimulation with the intrinsic hand tremor signal. The study will assess the efficacy of this novel approach to reduce hand tremor in PD patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Clinical diagnosis of Parkinson's disease based on UK Brain Bank criteria

• Patient exhibiting moderate to severe hand tremor

• Provision written informed consent by the patient

Locations
Other Locations
Germany
Universitätsklinikum Hamburg-Eppendorf
RECRUITING
Hamburg
Contact Information
Primary
Simone Zittel, Dr. med.
s.zittel-dirks@uke.de
+49 40 7410 53770
Time Frame
Start Date: 2025-04-16
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 10
Treatments
Experimental: Active-tACS
Patients receive an active tACS stimulation with 2-4 mA amplitude
Sham_comparator: Sham-tACS
Patients receive a tACS stimulation with 0 mA amplitude
Active_comparator: Unlocked-tACS
Patients receive an active tACS stimulation with 2-4 mA amplitude but without phase alignment between tremor and tACS
Sponsors
Leads: Universitätsklinikum Hamburg-Eppendorf

This content was sourced from clinicaltrials.gov