Network Based Repetitive Transcranial Magnetic Stimulation (rTMS) as an Intervention for Levodopa-induced Dyskinesia (LID) in Parkinson's Disease (PD)

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The proposed study investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for levodopa-induced dyskinesia (LID) in Parkinson's Disease (PD). Specifically, the study aims to determine whether patterned stimulation of the pre-supplementary motor area (pre-SMA) can delay the onset of LID after levodopa intake and reduce LID severity in PD patients. This study will provide critical insights into potential targets for rTMS treatment, optimal rTMS parameters, and the mechanisms underlying LID in Parkinson's disease.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Clinically established or probable PD

• Clinical Diagnostic Criteria for Parkinson's Disease

• Peak-of-dose levodopa-induced dyskinesia.

• Stable antiparkinsonian medicine for at least four weeks.

• Signed informed consent.

Locations
Other Locations
Denmark
DRCMR
RECRUITING
Hvidovre
Contact Information
Primary
Laura Sakalauskaite, MD
laura.sakalauskaite.01@regionh.dk
+45 38621184
Time Frame
Start Date: 2024-07-22
Estimated Completion Date: 2027-05-01
Participants
Target number of participants: 68
Treatments
Active_comparator: Gamma burst rTMS
Real stimulation with 4 pulses at the frequency of 130Hz repeating at 1 Hz will be delivered on the pre-SMA using the active side of the coil for 30 minutes
Sham_comparator: Sham gamma burts rTMS
Sham stimulation with 4 pulses at the frequency of 130Hz repeating at 1Hz will be delivered on the pre-SMA with a non-active side of the coil for 30 minutes
Active_comparator: Beta burst rTMS
Real stimulation with 4 pulses at the frequency of 20Hz repeating at 1 Hz be delivered on the pre-SMA using the active side of the coil for 30 minutes
Sham_comparator: Sham beta burst rTMS
Sham stimulation with 4 pulses at the frequency of 20Hz repeating at 1Hz will be delivered on the pre-SMA with a non-active side of the coil for 30 minutes
Sponsors
Leads: Danish Research Centre for Magnetic Resonance

This content was sourced from clinicaltrials.gov