Circulating Tumor DNA in Primary Mediastinal Large B-cell Lymphoma (PMBL)
The purpose of this study is to compare the predictive value in terms of specificity of circulating tumor DNA (ctDNA) and positron emission computed tomography (PET-CT) after 2 cycles of chemotherapy (C2), on the probability of obtaining a metabolic complete response after 4 cycles of induction chemotherapy (C4) in patients with primary mediastinal large B cell lymphoma (PMBL) receiving standard R-CHOP14 or R-ACVBP.
• Patient over 18 years of age,
• Suffering from a diffuse primary B lymphoma of the mediastinum, newly diagnosed locally on a biopsy with anatomopathological analysis according to the recommendations of the WHO 2016 classification of hematological malignancies,
• All stages (I-IV)
• All IPI scores (0-5)
• With mediastinal involvement,
• Untreated (apart from emergency corticosteroid therapy less than 2mg/kg/day for 7 days),
• Treatment with R-CHOP-14 or R-ACVBP with PET-CT guided strategy (delta SUVmax) to be initiated,
• Tumor fixation above liver background on pre-treatment FDG PET/CT/CT (Deauville score ≥4),
• Having signed the informed consent prior to any study procedure
• Affiliated or beneficiary of a social protection plan.