An Open-label, Single-arm, Multi-center Phase 2 Study to Evaluate the Efficacy and Safety of Abexinostat as Monotherapy in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)
Who is this study for? Adult patients with diffuse large B-cell lymphoma
What treatments are being studied? oral abexinostat
Status: Recruiting
Location: See all (23) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
An open-label, single-arm, multi-center phase 2 study to evaluate the efficacy and safety of abexinostat, as monotherapy in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL)
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Histologically confirmed diffuse large B-cell lymphoma (DLBCL);
• Have received only two prior standard therapy lines for diffuse large B-cell lymphoma (DLBCL) including anti- cluster of differentiation antigen (anti-CD20) antibody and cytotoxic therapy;
• Confirmed to be unresponsive to the last line of therapy, or have disease progression following the last line of therapy;
• Have at least one radiologically measurable lymph node or extranodal lymphoid malignant lesion;
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2;
• Meet various hematological, liver and renal function lab parameters.
Locations
Other Locations
China
Cancer Hospital Chinese Academy of Medical Sciences
RECRUITING
Beijing
China-Japan Friendship Hospital
RECRUITING
Beijing
Peking University Third Hospital
RECRUITING
Beijing
West China Hospital, Sichuan University
RECRUITING
Chengdu
The First Affiliate Hospital of Dalian Medical University
RECRUITING
Dalian
Fujian Medical University Union Hospital
RECRUITING
Fuzhou
Fujian Provincial Cancer Hospital
RECRUITING
Fuzhou
Cancer Center of Guangzhou Medical University
RECRUITING
Guangzhou
Sun Yai-Sen Memorial Hospital, Sun Yai-Sen University
RECRUITING
Guangzhou
Zhejiang Cancer Hospital
RECRUITING
Hangzhou
The Affiliated Tumor Hospital of Harbin Medical University
RECRUITING
Harbin
The First Hospital of Lanzhou University
RECRUITING
Lanzhou
Linyi Cancer Hospital
RECRUITING
Linyi
Nantong Tumor Hospital
RECRUITING
Nantong
Fudan University Shanghai Cancer Center
RECRUITING
Shanghai
Shanghai Jiao Tong University School Medicine
RECRUITING
Shanghai
Second People's Hospital of Shenzhen
RECRUITING
Shenzhen
The Forth Hospital of Hebei Medical University
RECRUITING
Shijiazhuang
First Hospital of Shanxi Medical University
RECRUITING
Taiyuan
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING
Wuhan
The Affiliated Hospital of Xuzhou Medical University
RECRUITING
Xuzhou
Henan Cancer Hospital
RECRUITING
Zhengzhou
The First Affiliated Hospital of Zhengzhou University