The Effects of 12-week Hydrogen-rich Water Consumption on Body Composition and Metabolic Biomarkers in Adults With Metabolic Syndrome and Varying Breath Hydrogen Levels
The HYDRO-RESPOND trial is a 12-week randomized controlled study investigating the effects of daily hydrogen-rich water (HRW) consumption on body composition and metabolic biomarkers in adults diagnosed with metabolic syndrome. The study also explores whether individual differences in baseline breath hydrogen levels influence response to HRW. Participants are randomly assigned to receive either HRW or a placebo, with outcomes including changes in body fat, waist circumference, glucose metabolism, lipid profiles, and inflammatory markers. The trial aims to determine the therapeutic potential of HRW and identify predictors of individual responsiveness.
• Age 30-65 years
• Metabolic syndrome (NHS) (at least 3 of the 5 following criteria):
‣ Waist circumference of ≥ 102 cm in men and ≥ 88 cm in women
⁃ Hypertriglyceridemia (≥ 1.695 mmol/L)
⁃ Low HDL-C (\< 1.04 mmol/dL in men and \< 1.30 mmol/dL in women)
⁃ High blood pressure (\> 130/85 mmHg)
⁃ High fasting glucose (\> 6.1 mmol/L)
• Not physically active
• Informed consent signed