A Randomized Controlled Trial Evaluating Fluid Resuscitation in Acute Pancreatitis: Dextran 40 and Ringer's Lactate (1:3 Ratio) Versus Ringer's Lactate Alone

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This clinical trial aims to learn if a combination of Dextran 40 and Ringer's lactate solution can improve fluid resuscitation in mild and moderate acute pancreatitis (AP) and prevent complications. The main questions it aims to answer are: Does early fluid resuscitation with Dextran 40 plus Ringer's lactate improve patient outcomes compared to Ringer's alone? Does this treatment reduce inflammation, organ failure, and the need for intensive care unit (ICU) admission? Researchers will compare Dextran 40 plus Ringer's lactate to Ringer's alone to see if the combination therapy is more effective in reducing disease severity and complications. Participants will: Receive either Dextran 40 plus Ringer's lactate (1:3 ratio) or Ringer's lactate alone. Have blood tests every 24 hours to measure inflammation and organ function. Be monitored for changes in disease severity, need for ICU admission, and hospitalization duration. This study will help determine the best fluid resuscitation strategy for treating mild and moderate acute pancreatitis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• adults (≥18 years) diagnosed with mild or moderate acute pancreatitis

• must provide written informed consent for study participation.

Locations
Other Locations
Romania
Spitalul Judetean de Urgenta Satu Mare
RECRUITING
Satu Mare
Contact Information
Primary
Costea Cristian PHD STUDENT, MEDICNE
drcostecristian@gmail.com
+40755874293
Time Frame
Start Date: 2022-01-10
Estimated Completion Date: 2025-05-12
Participants
Target number of participants: 100
Treatments
Experimental: Dextran 40 plus Ringer Lactat 1:3 ratio
50 patients with acute pancreatitis will receive Dextran 40 plus RInger Lactat 1:3 ratio early to admission in the hospital
Active_comparator: Ringer Lactat
50 patients will receive only Ringer Lactat
Sponsors
Leads: Satu Mare County Emergency Hospital

This content was sourced from clinicaltrials.gov